Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia

  • Oh, Ji Hyun (Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Oh, Dong Jun (Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Koo, So-My (Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Kim, Yang Ki (Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Kim, Ki Up (Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Kim, Hyun Jo (Department of Thoracic Surgery, Soonchunhyang University Hospital) ;
  • Kim, Dong Won (Department of Pathology, Soonchunhyang University Hospital) ;
  • Uh, Soo-Taek (Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital)
  • Received : 2015.04.22
  • Accepted : 2015.06.30
  • Published : 2015.10.30
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Abstract

Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids. A few reports showed treatment failure with macrolides in patients with COP who were resistant to steroids. In this report, we described two cases of COP who showed different responses to clarithromycin. One recovered completely, but the other gradually showed lung fibrosis with clarithromycin.

Keywords

References

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