Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Selection of Target Materials for GLP Genotoxic Tests by Searching the Mutagenicity Information of Chemicals by Occupational Safety and Health Act

산안법 관리대상물질의 변이원성 검색을 통한 GLP 유전독성 시험대상 후보물질의 선정

  • Rim, Kyung-Taek (Center for Chemicals, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Lim, Cheol-Hong (Center for Chemicals, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency) ;
  • Ahn, Byung-Joon (Center for Chemicals, Occupational Safety&Health Research Institute, Korea Occupational Safety&Health Agency)
  • 임경택 (안전보건공단 산업안전보건연구원 화학물질센터) ;
  • 임철홍 (안전보건공단 산업안전보건연구원 화학물질센터) ;
  • 안병준 (안전보건공단 산업안전보건연구원 화학물질센터)
  • Received : 2015.07.23
  • Accepted : 2015.09.22
  • Published : 2015.09.30
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Abstract

Objectives: There is a requirement to select target materials for mutagenicity(Genotoxicity) testing, so we determined to set the test priorities of them by searching the related database. Methods and Results: We searched a number of databases to find information on mutagenicity tests with chemicals under the Occupational Safety and Health Act(OSH Act), such as KOSHANET, National Toxicology Program(NTP), European Chemicals Agency(ECHA), US National Library of Medicine(NLM), and Genetic Toxicology Data Bank(GENE-TOX), as well as ChemIDplus webpage, and presented the information. Also we anticipated their hazards with ACToR sites to confirm the 58 mutagenicity(Genotoxicity) tests we will perform. Conclusions: We presented target materials for mutagenicity testing with specific GLP tests consisting of reverse mutation(Ames), chromosomal aberration and micronucleus test.

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References

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