Journal of Microbiology and Biotechnology

  • 제25권9호
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  • Pages.1532-1536
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  • 2015
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Probiotic Mixture KF Attenuates Age-Dependent Memory Deficit and Lipidemia in Fischer 344 Rats

  • Jeong, Jin-Ju (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Kim, Kyung-Ah (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Ahn, Young-Tae (R&BD Center, Korea Yakult Co., Ltd.) ;
  • Sim, Jae-Hun (R&BD Center, Korea Yakult Co., Ltd.) ;
  • Woo, Jae-Yeon (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Huh, Chul-Sung (Graduate School of International Agricultural Technology/GBST, Seoul National University) ;
  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
  • 투고 : 2015.05.06
  • 심사 : 2015.05.14
  • 발행 : 2015.09.28
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초록

To investigate the memory-enhancing effect of lactic acid bacteria, we selected the probiotic mixture KF, which consisted of Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (1 × 1011 CFU/g of each strain), and investigated its antilipidemic and memoryenhancing effects in aged Fischer 344 rats. KF (1 × 1010 CFU/rat/day), which was administered orally once a day (6 days per week) for 8 weeks, significantly inhibited age-dependent increases of blood triglyceride and reductions of HDL cholesterol (p < 0.05). KF restored agereduced spontaneous alternation in the Y-maze task to 94.4% of that seen in young rats (p < 0.05). KF treatment slightly, but not significantly, shortened the escape latency daily for 4 days. Oral administration of KF restored age-suppressed doublecortin and brain-derived neurotrophic factor expression in aged rats. Orally administered KF suppressed the expression of p16, p53, and cyclooxygenase-2, the phosphorylation of Akt and mTOR, and the activation of NF-κB in the hippocampus of the brain. These findings suggest that KF may ameliorate age-dependent memory deficit and lipidemia by inhibiting NF-κB activation.

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참고문헌

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