The Korean Journal of Pain

  • 제28권4호
  • /
  • Pages.236-243
  • /
  • 2015
  • /
  • 2005-9159(pISSN)
  • /
  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
권호 표지
DOI QR코드

DOI QR Code

A New Rat Model of Cisplatin-induced Neuropathic Pain

  • Lin, Hai (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Heo, Bong Ha (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Yoon, Myung Ha (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School)
  • 투고 : 2015.06.10
  • 심사 : 2015.07.15
  • 발행 : 2015.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Chemotherapy-induced peripheral neuropathy is a major side effect of anti-cancer drugs, and our knowledge of its mechanisms is lacking. Several models for chemotherapy-induced neuropathy have been introduced. However, the outcomes of these models differ significantly among laboratories. Our object was to create a model of chemotherapy-induced neuropathy in rats with cancer. Methods: Female Sprague-Dawley rats were used. Mammary rat metastasis tumor (MRMT-1) cells were implanted subcutaneously in rats. Chemotherapy-induced peripheral neuropathy was induced by injection of cisplatin once a day for four days. The responses to mechanical and thermal stimuli were examined using von Frey filaments, acetone, and radiant heat. Results: Cisplatin (2 mg/kg/day) produced mechanical allodynia, while it did not induce cold allodynia or thermal hyperalgesia. This dose of cisplatin could work successfully against cancer. Body weight loss was not observed in cisplatin-treated rats, nor were other abnormal behaviors noted in the same rats. Conclusions: Repeated injection of intraperitoneal cisplatin induced peripheral neuropathic pain in rats. Thus, this type of rat model has broad applicability in studies related to searching for the mechanism of cisplatin-induced mechanical allodynia and agents for the treatment of neuropathic pain.

키워드

참고문헌

  1. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J Peripher Nerv Syst 2008; 13: 27-46. https://doi.org/10.1111/j.1529-8027.2008.00156.x
  2. Hoke A. Animal models of peripheral neuropathies. Neurotherapeutics 2012; 9: 262-9. https://doi.org/10.1007/s13311-012-0116-y
  3. Franconi G, Manni L, Schroder S, Marchetti P, Robinson N. A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy. Evid Based Complement Alternat Med 2013; 2013: 516916.
  4. Authier N, Balayssac D, Marchand F, Ling B, Zangarelli A, Descoeur J, et al. Animal models of chemotherapy-evoked painful peripheral neuropathies. Neurotherapeutics 2009; 6:620-9. https://doi.org/10.1016/j.nurt.2009.07.003
  5. Cavaletti G, Petruccioli MG, Tredici G, Marmiroli P, Barajon I, Fabbrica D, et al. Effects of repeated administration of low doses of cisplatin on the rat nervous system. Int J Tissue React 1991; 13: 151-7.
  6. Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer 2008; 44: 1507-15. https://doi.org/10.1016/j.ejca.2008.04.018
  7. Jeong S, Lee SH, Kim YO, Yoon MH. Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats. J Korean Med Sci 2013; 28: 1238-43. https://doi.org/10.3346/jkms.2013.28.8.1238
  8. Choi Y, Yoon YW, Na HS, Kim SH, Chung JM. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain 1994; 59: 369-76. https://doi.org/10.1016/0304-3959(94)90023-X
  9. Marmiroli P, Nicolini G, Miloso M, Scuteri A, Cavaletti G. The fundamental role of morphology in experimental neurotoxicology:the example of chemotherapy-induced peripheral neurotoxicity. Ital J Anat Embryol 2012; 117: 75-97.
  10. Rostock M, Jaroslawski K, Guethlin C, Ludtke R, Schroder S, Bartsch HH. Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. Evid Based Complement Alternat Med 2013; 2013: 349653.
  11. Al Moundhri MS, Al-Salam S, Al Mahrouqee A, Beegam S, Ali BH. The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies. J Med Toxicol 2013; 9: 25-33. https://doi.org/10.1007/s13181-012-0239-x
  12. Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesth Analg 2013; 116: 224-31. https://doi.org/10.1213/ANE.0b013e31826e1007
  13. Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol 2006; 6:836-48. https://doi.org/10.1038/nri1961
  14. Authier N, Gillet JP, Fialip J, Eschalier A, Coudore F. An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections. Exp Neurol 2003; 182: 12-20. https://doi.org/10.1016/S0014-4886(03)00003-7
  15. Ta LE, Low PA, Windebank AJ. Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli. Mol Pain 2009; 5: 9. https://doi.org/10.1186/1744-8069-5-9

피인용 문헌

  1. Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors vol.8, pp.7, 2017, https://doi.org/10.1021/acschemneuro.6b00401
  2. Mitigation of cisplatin-induced peripheral neuropathy by canagliflozin in rats vol.391, pp.9, 2018, https://doi.org/10.1007/s00210-018-1521-5
  3. The effect of thiamine and its metabolites on peripheral neuropathic pain induced by cisplatin in rats vol.67, pp.2, 2018, https://doi.org/10.1538/expanim.17-0090
  4. Computational and Pharmacological Investigation of (E)-2-(4-Methoxybenzylidene)Cyclopentanone for Therapeutic Potential in Neurological Disorders vol.14, pp.None, 2020, https://doi.org/10.2147/dddt.s234345
  5. Insights into platinum-induced peripheral neuropathy–current perspective vol.15, pp.9, 2015, https://doi.org/10.4103/1673-5374.276321
  6. SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair vol.130, pp.6, 2015, https://doi.org/10.1172/jci123159
  7. Antinociceptive role of neurotensin receptor 1 in rats with chemotherapy-induced peripheral neuropathy vol.33, pp.4, 2020, https://doi.org/10.3344/kjp.2020.33.4.318
  8. Prostaglandin D2 contributes to cisplatin-induced neuropathic pain in rats via DP2 receptor in the spinal cord vol.34, pp.1, 2015, https://doi.org/10.3344/kjp.2021.34.1.27
  9. Boric acid improves the behavioral, electrophysiological and histological parameters of cisplatin-induced peripheral neuropathy in rats vol.70, pp.None, 2022, https://doi.org/10.1016/j.jtemb.2021.126917