References
- Nettleship, A., Henshaw, P.S. and Meyer, H.L. (1943) Induction of pulmonary tumors in mice with ethyl carbamate. J. Nat. Cancer Inst., 4, 309-331.
- Zimmerli, B. and Schlatter, J. (1991) Ethyl carbamate: analytical methodology, occurrence, formation, biological activity and risk assessment. Mutat. Res., 259, 325-350. https://doi.org/10.1016/0165-1218(91)90126-7
- Mirvish, S.S. (1968) The carcinogenic action and metabolism of urethane and N-hydroxyurethane. Adv. Cancer Res., 11, 1-42.
- National Toxicology Program. (1983) Report on Carcinogens, Thirteenth Edition: Urethane. Available from: http://ntp.niehs.nih.gov/ntp/roc/content/profiles/urethane.pdf. Accessed July 20, 2015.
- Beland, F.A., Benson, R.W., Mellick, P.W., Kovatch, R.M., Roberts, D.W., Fang, J.L. and Doerge, D.R. (2005) Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice. Food Chem. Toxicol., 43, 1-19. https://doi.org/10.1016/j.fct.2004.07.018
- IARC (International Agency for Research on Cancer). (1974) Urethane. IARC Monogr. Carcinog. Risks Hum., 7, 111-140.
- IARC (International Agency for Research on Cancer). (2007) International agency for research. 96, alcoholic beverage consumption and ethyl carbamate (urethane) 6-13 February 2007 1-5. World Health Organization, Lyon, France. Available from: http://monographs.iarc.fr/ENG/Meetings/vol96-summary.pdf. Accessed December 10 2014.
- FAO/WHO (Food and Agriculture Organisation/World Health Organisation). (2005) Summary and conclusions of the sixtyfourth meeting of the joint meeting of the joint FAO/WHO expert committee of food additives (WHO Food Additives Series 30) world health organisation, Geneva. WHO Tech. Rep. Ser. 928, 1-47. Available from: http://www.who.int/ipcs/food/jecfa/summaries/en/summary_report_64_final.pdf. Accessed July 25 2013.
- Jagerdeo, E., Dugar, S., Foster, G.D. and Schenck, H. (2002) Analysis of ethyl carbamate in wines using solid-phase extraction and multidimensional gas chromatography/mass spectrometry. J. Agric. Food Chem., 50, 5797-5802. https://doi.org/10.1021/jf025559s
- Lachenmeier, D.W., Schehl, B., Kuballa, T., Frank, W. and Senn, T. (2005) Retrospective trends and current status of ethyl carbamate in German stone-fruit spirits. Food Addit. Contam., 22, 397-405. https://doi.org/10.1080/02652030500073360
- EFSA. (2007) Ethyl carbamate and hydrocyanic acid in food and beverages. EFSA J., 551, 1-44.
- Wu, H., Chen, L., Pan, G., Tu, C., Zhou, X. and Mo, L. (2012) Study on the changing concentration of ethyl carbamate in yellow rice wine during production and storage by gas chromatography/mass spectrometry. Eur. Food Res. Technol., 235, 779-782. https://doi.org/10.1007/s00217-012-1807-7
- Aresta, M., Boscolo, M. and Franco, D.W. (2001) Copper(II) catalysis in cyanate conversion into ethyl carbamate in spirits, and relevant reactions. J. Agric. Food Chem., 49, 2819-2824. https://doi.org/10.1021/jf001346w
- Wu, P., Pan, X., Wang, L., Shen, X. and Yang, D. (2012) A survey of ethyl carbamate in fermented foods and beverages from Zhejiang, China. Food Control, 23, 286-288. https://doi.org/10.1016/j.foodcont.2011.07.014
- Sen, N.P., Seaman, S.W., Boyle, M. and Weber, D. (1993) Methyl carbamate and ethyl carbamate in alcoholic beverages and other fermented foods. Food Chem., 4, 359-366.
- Dennis, M.J., Massey, R.C., Ginn, R., Parker, I., Crews, C., Zimmerli, B., Zoller, O., Rhyn, P. and Osborne, B. (1997) The effect of azodicarbonamide concentrations on ethyl carbamate concentrations in bread and toast. Food Addit. Contam., 14, 95-100. https://doi.org/10.1080/02652039709374502
- Canas, B.J., Diachenko, G.W. and Nyman, P.J. (1997) Ethyl carbamate levels resulting from azodicarbonamide use in bread. Food Addit. Contam., 14, 89-94. https://doi.org/10.1080/02652039709374501
- Xia, Q., Yuan, H., Wu, C., Zheng, J., Zhang, S., Shen, C., Yi, B. and Zhou, R. (2014) An improved and validated sample cleanup method for analysis of ethyl carbamate in Chinese liquor. J. Food Sci., 79, 1854-1860. https://doi.org/10.1111/1750-3841.12567
- Kim, Y.K., Koh, E., Chung, H.J. and Kwon, H. (2000) Determination of ethyl carbamate in some fermented Korean foods and beverage. Food Addit. Contam., 17, 469-475. https://doi.org/10.1080/02652030050034055
- Lim, H.S. and Lee, K.G. (2011) Development and validation of analytical methods for ethyl carbamate in various fermented foods. Food Chem., 126, 1373-1379. https://doi.org/10.1016/j.foodchem.2010.11.110
- Canas, B.J., Havery, D.C. and Joe, F.L. Jr. (1988) Rapid gas chromatographic method for determining ethyl carbamate in alcoholic beverages with thermal energy analyzer detection. J. Assoc. Off. Anal. Chem., 71, 509-511.
- Hansnip, S., Crews, C., Potter, N., Christy, J., Chan, D., Bondu, T., Matthews, W., Walters, B. and Patel, K. (2007) Survey of ethyl carbamate in fermented foods sold in the United Kingdom in 2004. J. Agric. Food Chem., 55, 2755-2759. https://doi.org/10.1021/jf063121c
- Lachenmeier, D.W., Nerlich, U. and Kuballa, T. (2006) Automated determination of ethyl carbamate in stone-fruit spirits using headspace solid-phase microextraction and gas chromatography-tandem mass spectrometry. J. Chromatogr. A, 1108, 116-120. https://doi.org/10.1016/j.chroma.2005.12.086
- Nóbrega, I.C., Pereira, G.E., Silva, M., Pereira, E.V., Medeiros, M.M., Telles, D.L., Albuquerque, E.C. Jr., Oliveira, J.B. and Lachenmeier, D.W. (2015) Improved sample preparation for GC-MS-SIM analysis of ethyl carbamate in wine. Food Chem., 177, 23-28. https://doi.org/10.1016/j.foodchem.2014.12.031
- AOAC. (1997) AOAC official method 944.07: ethyl carbamate in alcoholic beverages and soy sauce. In: AOAC official methods of analysis (17 edition). J. AOAC Int. Gaithersburg, MD, USA, pp. 14-15.
- Dennis, M.J., Howarth, N., Massey, R.C., Parker, I., Scotter, M. and Startin, J.R. (1986) Method for the analysis of ethyl carbamate in alcoholic beverages by capillary gas chromatography. J. Chromatogr. A, 369, 193-198. https://doi.org/10.1016/S0021-9673(00)90115-8
- Fauhl, C., Catsburg, R. and Wittkowski, R. (1993) Determination of ethyl carbamate in soy sauces. Food Chem., 48, 313-316. https://doi.org/10.1016/0308-8146(93)90147-8
- Tang, A.S., Chung, S.W., Kwong, K., Xiao, Y., Chen, M.Y., Ho, Y.Y. and Ma, S.W. (2011) Ethyl carbamate in fermented foods and beverages: dietary exposure of the Hong Kong population in 2007-2008. Food Addit. Contam. Part B, 4, 195-204. https://doi.org/10.1080/19393210.2011.605524
- Ye, C.W., Zhang, X.N., Gao, Y.L., Wang, Y.L., Pan, S.Y. and Li, X.J. (2012) Multiple headspace solid-phase microextraction after matrix modification for avoiding matrix effect in the determination of ethyl carbamate in bread. Anal. Chim. Acta, 710, 75-80. https://doi.org/10.1016/j.aca.2011.10.030
- Zhang, Y. and Zhang, J. (2008) Optimization of headspace solid-phase microextraction for analysis of ethyl carbamate in alcoholic beverages using a face-centered cube central composite design. Anal. Chim. Acta, 627, 212-218. https://doi.org/10.1016/j.aca.2008.08.014
- Perestrelo, R., Petronilho, S., Câmara, J.S. and Rocha, S.M. (2010) Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with solid phase microextraction as a powerful tool for quantification of ethyl carbamate in fortified wines. The case study of Madeira wine. J. Chromatogr. A, 1217, 3441-3445. https://doi.org/10.1016/j.chroma.2010.03.027
- Kim, D.H., Jang, H.S., Choi, G.I., Kim, H.J., Kim, H.J., Kim, H.L. and Kim, K.S. (2013) Determination of residue levels of ethyl carbamate in alcoholic beverages by gas chromatography/tandem mass spectrometry. J. Food Hyg. Saf., 1, 63-68.
- Herbert, P., Santos, L., Bastos, M., Barros, P. and Alves, A. (2002) New HPLC method to determine ethyl carbamate in alcoholic beverages using fluorescence detection. J. Food Sci., 67, 1616-1620. https://doi.org/10.1111/j.1365-2621.2002.tb08693.x
- Solymosy, F., Antoni, F. and Fedorcsak, I. (1978) On the amounts of urethane formed in diethyl pyrocarbonate treated beverages. J. Agric. Food Chem., 26, 500-503. https://doi.org/10.1021/jf60216a025
- Hara, S., Yoshizawa, K. and Nakamura, K.I. (1988) Formation of ethyl carbamate in model alcoholic beverages containing urea or related compounds. Nippon Jozo Kjiokaishi, 83, 57-63.
- Dahabieh, M.S., Husnik, J.I. and Van Vuuren, H.J. (2010) Functional enhancement of sake yeast strains to minimize the production of ethyl carbamate in sake wine. J. Appl. Microbiol., 109, 963-973. https://doi.org/10.1111/j.1365-2672.2010.04723.x
- Azevedo, Z., Couto, J.A. and Hogg, T. (2002) Citrulline as the main precursor of ethyl carbamate in model fortified wines inoculated with Lactobacillus hilgardii: a marker of the levels in a spoiled fortified wine. Lett. Appl. Microbiol., 34, 32-36. https://doi.org/10.1046/j.1472-765x.2002.01045.x
- Matsudo, T., Aoki, T., Abe, K., Fukuta, N., Higuchi, T., Sasaki, M. and Uchida, K. (1993) Determination of ethyl carbamate in soy sauce and its possible precursor. J. Agric. Food Chem., 41, 352-356. https://doi.org/10.1021/jf00027a003
- Taki, N., Imamura, L., Takebe, S. and Kobashi, K. (1992) Cyanate as a precursor of ethyl carbamate in alcoholic beverages. Jpn. J. Toxicol. Environ. Health, 38, 498-505. https://doi.org/10.1248/jhs1956.38.498
- Wucherpfennig, K., Clauss, E. and Konja, G. (1987) Formation of ethyl carbamate in alcoholic beverages based on the maraschino cherry. Dtsch. Lebensm. Rundsch., 83, 344-349.
- Hashiguchi, T., Horii, S., Izu, H. and Sudo, S. (2010) The concentration of ethyl carbamate in commercial ume (Prunus mume) liqueur products and a method of reducing it. Biosci. Biotechnol. Biochem., 74, 2060-2066. https://doi.org/10.1271/bbb.100364
- Baumann, U. and Zimmerli, B. (1988) Accelerated formation of ethyl carbamate in spirits. Mitt. Geb. Lebensmittelunters. Hyg., 22, 175-185.
- Hansnip, S., Caputi, A., Crews, C. and Brereton, P. (2004) Effects of storage time and temperature on the concentration of ethyl carbamate and its precursors in wine. Food Addit. Contam., 21, 1155-1161. https://doi.org/10.1080/02652030400019851
- Yoshizawa, K., Takahashi, K. and Sato, K. (1988) Changes of urea content in rice and sake moromi during sake making process. Nippon Jozo Kyokaishi, 83, 136-141.
- Arena, M.E. and Manca de Nadra, M.C. (2005) Influence of ethanol and low pH on arginine and citrulline metabolism in lactic acid bacteria from wine. Res. Microbiol., 156, 858-864. https://doi.org/10.1016/j.resmic.2005.03.010
- Fidaleo, M., Esti, M. and Moresi, M. (2006) Assessment of urea degradation rate in model wine solutions by urease from Lactobacillus fermentum. J. Agric. Food Chem., 54, 6226-6235. https://doi.org/10.1021/jf060934s
- Kobashi, K., Takebe, S. and Sakai, T. (1988) Removal of urea from alcoholic beverages with an acid urease. J. Appl. Toxicol., 8, 73-74. https://doi.org/10.1002/jat.2550080112
- Pieper, H.J., Seibold, R., Luz, E. and Jung, O. (1992) Reduction of the ethyl carbamate concentration in manufacture of Kirsch (cherry spirit). Kleinbrennerei, 44, 125-130.
- Schehl, B., Senn, T., Lachenmeier, D.W., Rodicio, R. and Heinisch, J.J. (2007) Contribution of the fermenting yeast strain to ethyl carbamate generation in stone fruit spirits. Appl. Microbiol. Biotechnol., 74, 843-850. https://doi.org/10.1007/s00253-006-0736-4
- Kitamoto, K., Oda-Miyazaki, K., Gomi, K. and Kumagai, C. (1993) Mutant isolation of non-urea producing sake yeast by positive selection. J. Ferment. Bioeng., 75, 359-363. https://doi.org/10.1016/0922-338X(93)90134-T
- Coulon, J., Husnik, J.I., Inglis, D.L., van der Merwe, G.K., Lonvaud, A., Erasmus, D.J. and van Vuuren, H.J.J. (2006) Metabolic engineering of Saccharomyces cerevisiae to minimize the production of ethyl carbamate in wine. Am. J. Enol. Vitic., 57, 113-124.
- Arena, M.E., Saguir, F.M. and Manca de Nadra, M.C. (1999) Ariginine, citrulline and ornithine metabolism by lactic acid bacteria from wine. Int. J. Food Microbiol., 52, 155-161. https://doi.org/10.1016/S0168-1605(99)00133-6
- Bolarinwa, I.F., Orfila, C. and Morgan, M.R. (2014) Amygdalin content of seeds, kernels and food products commerciallyavailable in the UK. Food Chem., 152, 133-139. https://doi.org/10.1016/j.foodchem.2013.11.002
- Hwang, L.H., Kim, A.K., Park, K.A., Kim, J.Y., Hwang, I.S. and Chae, Y.Z. (2009) The effect of raw material, alcohol content, and trans-resveratrol on the formation of ethyl carbamate in plum wine. J. Food Hyg. Saf., 24, 194-199.
- Battaglia, R., Conacher, H.B. and Page, B.D. (1990) Ethyl carbamate (urethane) in alcoholic beverages and foods: a review. Food Addit. Contam., 7, 477-496. https://doi.org/10.1080/02652039009373910
- Park, S.K., Yoon, T. and Choi, D. (2008) Analysis of ethyl carbamate in alcoholic beverages. Anal. Sci. Technol., 21, 53-57.
- Adams, C. and van Vuuren, H.J.J. (2010) Effect of timing of diammonium phosphate addition to fermenting grape must on the production of ethyl carbamate in wine. Am. J. Enol. Vitic., 61, 125-129.
- Weltring, A., Rupp, M., Arzberger, U., Rothenbuecher, L., Koch, H., Sproll, C. and Lachenmeier, D.W. (2006) Ethyl carbamate: analysis of questionnaires about production methods of stone-fruit spirits at German small distilleries. Dtsch. Lebensm. Rundsch., 102, 97-101.
- Park, S.R., Ha, S.D., Yoon, J.H., Lee, S.Y., Hong, K.P., Lee, E.H., Yeom, H.J., Yoon, N.G. and Bae, D.H. (2009) Exposure to ethyl carbamate in alcohol-drinking and nondrinking adults and its reduction by simple charcoal filtration. Food Control, 20, 946-952. https://doi.org/10.1016/j.foodcont.2009.02.006
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