Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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RNA Binding Proteins and its Regulation of Gene Expression

RNA 결합 단백질과 유전자 발현조절

  • Roh, Kyung Hee (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kang, Han-Chul (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Jong-Bum (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Hyun-UK (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Lee, Kyung-Ryeol (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Sun Hee (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration)
  • Received : 2015.01.29
  • Accepted : 2015.03.19
  • Published : 2015.09.30
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Abstract

The role of RNA-binding proteins (RBPs) to regulate expression of genes seems to be very important. RBPs play important roles in RNA related bioprocess such as transcription, pre-mRNA splicing, polyadenylation, transport, localization, translation, turn over and maintenance of structure. Despite of many researches on RNA binding proteins, detailed mechanisms of these proteins have not been fully understood. It seems that many parts of RBPs remains unknown and should be characterized for the better understanding of gene expression. Recently, genetic, biochemical, and bioinformatic analysis of genomes revealed a vast array of RBPs and many parts are interesting to understand bioprocessing including gene expression.

RNA 결합 단백질들이 유전자 조절의 다양한 범위에 작용한다는 사실이 아주 중요하다. 유전자의 전사에 관련된 유전자 조절이 많이 연구가 되었어도 RNA의 조절에 관한 연구는 상대적으로 부진한 편이다. RNA 결합 단백질들은 RNA와 관련되는 각종 과정, 예를 들면 전사, pre-mRNA splicing, polyadenylation, 수송, 위치화, 번역, 분해 및 구조의 유지 등 다양한 범위에서 작용을 하고 있다. RNA 결합 단백질들의 많은 부분들이 아직 잘 알려지지 않고 있으며 유전자 발현에 대해 더 잘 이해하기 위해 이러한 부분의 연구가 더 수행되어야 한다. 최근에 유전학, 생화 학, 및 유전자들의 생물정보학의 발달 등으로 인하여. RNA 결합 단백질들의 다양한 분야들이 알려지고 있으며 이러한 부분들이 많은 관심을 받고 있다.

Keywords

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