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Clinical Characteristics Associated with Long-term Survival in Metastatic Gastric Cancer after Systemic Chemotherapy

  • Kadowaki, Shigenori (Department of Clinical Oncology, Aichi Cancer Center Hospital) ;
  • Komori, Azusa (Department of Clinical Oncology, Aichi Cancer Center Hospital) ;
  • Takahari, Daisuke (Department of Clinical Oncology, Aichi Cancer Center Hospital) ;
  • Ura, Takashi (Department of Clinical Oncology, Aichi Cancer Center Hospital) ;
  • Ito, Seiji (Department of Gastroenterological Surgery, Aichi Cancer Center Hospital) ;
  • Tajika, Masahiro (Department of Endoscopy, Aichi Cancer Center Hospital) ;
  • Niwa, Yasumasa (Department of Endoscopy, Aichi Cancer Center Hospital) ;
  • Oze, Isao (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute) ;
  • Muro, Kei (Department of Clinical Oncology, Aichi Cancer Center Hospital)
  • 발행 : 2015.08.03

초록

Background: Systemic chemotherapy for patients with metastatic gastric cancer (MGC) is generally palliative, although some patients experience long-term survival after treatment. Thus, we identified clinical characteristics that are associated with long-term survival of patients with MGC after palliative chemotherapy. Materials and Methods: We retrospectively reviewed 514 MGC patients who received systemic chemotherapy at our institution from 2001 to 2008. To identify clinical predictors of survival beyond 2 years, multivariate logistic regression analyses were performed, and 5-year survival rates were estimated among MGC patients following chemotherapy. Results: Among 514 patients, 96 (19%) and 16 (3%) survived beyond 2 and 5 years, respectively, and performance status of 0 or 1 (odds ratio [OR]=3.39; p=0.01), previous gastrectomy (OR=1.86; p=0.01), single metastatic site (OR=1.80; p=0.03), and normal alkaline phosphatase levels (OR=2.81; p<0.01) were identified as independent predictors of long-term survival. Of the 16 5-year survivors, six were alive at the end of the study and showed no evidence of disease despite cessation of chemotherapy. Conclusions: The present data demonstrate distinct clinical characteristics that are associated with long-term survival of MGC patients, and indicated that palliative chemotherapy can be curative in highly selected patients.

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참고문헌

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피인용 문헌

  1. Factors Affecting Long Term Survival for Metastatic Gastric Cancer Treated with Chemotherapy vol.16, pp.2, 2016, https://doi.org/10.7704/kjhugr.2016.16.2.97
  2. Challenges in molecular targeted therapy for gastric cancer: considerations for efficacy and safety vol.16, pp.3, 2017, https://doi.org/10.1080/14740338.2017.1273348