Asian Pacific Journal of Cancer Prevention

  • 제16권13호
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  • Pages.5421-5425
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Growth Hormone 1 T1663A Polymorphism, Recreational Physical Activity and BMI, and Breast Cancer Risk in Chinese Women

  • Gao, Chang-Ming (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Ding, Jian-Hua (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Wu, Jian-Shong (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Cao, Hai-Xia (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Li, Su-Ping (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Liu, Yan-Ting (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Tang, Jin-Hai (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Tajima, Kazuo (Dept. of Public Health & Occupational Medicine, Mie University Graduate School of Medicine)
  • 발행 : 2015.08.03
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초록

To evaluate the relationship between the growth hormone 1 (GH1) T1663A polymorphism, recreational physical activity and body mass index (BMI) with reference to breast cancer, we conducted a case-control study with 669 cases of breast cancer and 682 population-based controls in Jiangsu Province, China. A structured questionnaire was used to elicit detailed information. All subjects completed an in-person interview. GH1 genotypes were identified using PCR-RFLP methods. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of GH1 genotypes was not significantly different between controls and cases ($x^2$=2.576, P=0.276). Results of stratified analysis by the participation status of the recreational physical activity showed that the persons with GH1 A allele were at a decreased risk of breast cancer (adjusted-OR=0.66; 95% CI, 0.50-0.87) only among inactive individuals. Stratified analysis by BMI showed that the genotype A/A was associated with a decreased risk of breast cancer only among individuals of the BMI <25 (adjusted-OR=0.80; 95% CI, 0.66-0.98). The findings of this study suggest that recreational physical activity and BMI may modify any association between the GH1 T1663A polymorphism and breast cancer risk.

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