Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

  • Published : 2015.04.29
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Abstract

Background: This case-control study aimed to determine if there were any associations between the two single nucleotide polymorphisms (SNPs) in Gc, rs7041 (Asp416Glu) and rs4588 (Thr420Lys) and 3 common cancers (breast, lung and colorectal) in Thai patients. Materials and Methods: Two hundred and eighty two colorectal, 101 breast and 113 lung cancer patients were recruited from one institute during 2011-2013. The controls were age-matched volunteers who had a negative history of index cancers. In addition, vitamin D levels were compared among different genotypes in the 2 SNPs. Results: The minor allele frequencies of rs7041 (G) and rs4588 (A) were 0.32 and 0.24, respectively. Under the dominant model, the study found significant associations between minor-allele genotypes of the SNP rs7041 (TG/GG) and lung cancer (odds ratio [OR] 1.78, 95% CI 1.05-3.03). When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minor-allele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37). When SNP combinations (rs7041-rs4588) were examined, the TT-CA combination had a significant protective association with lung cancer (OR 0.44, 95% CI 0.22-0.85). On evaluation of serum 25(OH)D levels in 205 individuals without cancer (males 144, females 61), the proportion of subjects with low serum vitamin D (< 20 ng/ml) in those harboring CA or AA genotypes of rs4588 (41.7%) was significantly higher than the CC genotype (15.5%, p-value < 0.01). Conclusions: Genetic polymorphisms in Gc were associated with lung and colorectal cancers in Thai patients. Lower serum 25(OH)D in minor variants of rs4588 may explain this association.

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References

  1. Abbas S, Linseisen J, Slanger T, et al (2008). The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev, 17, 1339-43. https://doi.org/10.1158/1055-9965.EPI-08-0162
  2. Ahn J, Yu K, Stolzenberg-Solomon R, et al (2010). Genome-wide association study of circulating vitamin D levels. Hum Mol Genet, 19, 2739-45. https://doi.org/10.1093/hmg/ddq155
  3. Anderson LN, Cotterchio M, Cole DE, et al (2011). Vitamin D-related genetic variants, interactions with vitamin D exposure, and breast cancer risk among Caucasian women in Ontario. Cancer Epidemiol Biomarkers Prev, 20, 1708-17. https://doi.org/10.1158/1055-9965.EPI-11-0300
  4. Anic GM, Weinstein SJ, Mondul AM, et al (2014). Serum vitamin D, vitamin D binding protein, and risk of colorectal cancer. PLoS One, 9, 102966. https://doi.org/10.1371/journal.pone.0102966
  5. Bai Y, Yu Y, Yu B, et al (2009). Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China. BMC Med Genet, 10, 125. https://doi.org/10.1186/1471-2350-10-125
  6. Borradale D, Kimlin M (2009). Vitamin D in health and disease: an insight into traditional functions and new roles for the 'sunshine vitamin. Nutr Res Rev, 22, 118-36.
  7. Chupeerach C, Tungtrongchitr A, Phonrat B, et al (2012). Association of Thr420Lys polymorphism in DBP gene with fat-soluble vitamins and low radial bone mineral density in postmenopausal Thai women. Biomarkers Med, 6, 103-8. https://doi.org/10.2217/bmm.11.88
  8. Engelman CD, Fingerlin TE, Langefeld CD, et al (2008). Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab, 93, 3381-8. https://doi.org/10.1210/jc.2007-2702
  9. Gandini S, Gnagnarella P, Serrano D, et al (2014). Vitamin D receptor polymorphisms and cancer. Adv Exp Med Biol, 810, 69-105.
  10. Holick MF (2007). Vitamin D deficiency. N Engl J Med, 357, 266-81. https://doi.org/10.1056/NEJMra070553
  11. Kidd LC, Paltoo DN, Wang S, et al (2005). Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk. Prostate, 64, 272-82. https://doi.org/10.1002/pros.20204
  12. Mahmoudi T, Karimi K, Arkani M, et al (2014). Lack of associations between vitamin D metabolism-related gene variants and risk of colorectal cancer. Asian Pac J Cancer Prev, 15, 957-61. https://doi.org/10.7314/APJCP.2014.15.2.957
  13. Malik S, Fu L, Juras DJ, et al (2013). Common variants of the vitamin D binding protein gene and adverse health outcomes. Crit Rev Clin Lab Sci, 50, 1-22. https://doi.org/10.3109/10408363.2012.750262
  14. McCullough ML, Stevens VL, Diver WR, et al (2007). Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. Breast Cancer Res, 1-9.
  15. Mocellin S (2011). Vitamin D and cancer: deciphering the truth. Biochim Biophys Acta, 1816, 172-8.
  16. National Cancer Institute of Thailand (2011). Cancer Registry.
  17. Oh JJ, Byun SS, Lee SE, et al (2014). Genetic variations in VDR associated with prostate cancer risk and progression in a Korean population. Gene, 533, 86-93. https://doi.org/10.1016/j.gene.2013.09.119
  18. Pani MA, Regulla K, Segni M, et al (2002). A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. J Clin Endocrinol Metab, 87, 2564-7.
  19. Poynter JN, Jacobs ET, Figueiredo JC, et al (2010). Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the colon cancer family registry. Cancer Epidemiol Biomarkers Prev, 19, 525-36. https://doi.org/10.1158/1055-9965.EPI-09-0662
  20. Powe CE, Evans MK, Wenger J, et al (2013). Vitamin D-Binding Protein and Vitamin D Status of Black Americans and White Americans. N Engl J Med, 369, 1991-2000. https://doi.org/10.1056/NEJMoa1306357
  21. Robien K, Butler LM, Wang R, et al (2013). Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore. Br J Nutr, 109, 493-502. https://doi.org/10.1017/S0007114512001675
  22. Santos BR, Mascarenhas LP, Boguszewski MC, et al (2013). Variations in the vitamin D-binding protein (DBP) gene are related to lower 25-hydroxyvitamin D levels in healthy girls: a cross-sectional study. Horm Res Paediatr, 79, 162-8. https://doi.org/10.1159/000348847
  23. Sinotte M, Diorio C, Berube S, et al (2009). Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr, 89, 634-40. https://doi.org/10.3945/ajcn.2008.26445
  24. Speeckaert M, Huang G, Delanghe JR, et al (2006). Biological and clinical aspects of the vitamin D binding protein (Gcglobulin) and its polymorphism. Clin Chim Acta, 372, 3-42.
  25. Taylor JA, Horvomen A, Watson M, et al (1996). Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Res, 56, 4108-10.
  26. Wang TJ, Zhang F, Richards JB, et al (2010). Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet, 376, 180-8. https://doi.org/10.1016/S0140-6736(10)60588-0
  27. Weinstein SJ, Mondul AM, Kopp W, et al (2013). Circulating 25-hydroxyvitamin D, vitamin D binding protein, and risk of prostate cancer. Int J Cancer, 132, 2940-7. https://doi.org/10.1002/ijc.27969
  28. Weinstein SJ, Purdue MP, Smith-Warner SA (2014). Serum 25-hydroxyvitamin D, vitamin D binding protein and risk of colorectal cancer in the prostate, lung, colorectal and ovarian cancer screening trial. Int J Cancer, 136, 654-64
  29. Yu K, Yang J, Jiang Y, et al (2014). Vitamin D receptor bsmi polymorphism and colorectal cancer risk: an updated analysis. Asian Pac J Cancer Prev, 15, 4801-7. https://doi.org/10.7314/APJCP.2014.15.12.4801
  30. Zhang Z, He JW, Fu WZ, et al (2013). An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population. J Bone Miner Res, 28, 1784-92. https://doi.org/10.1002/jbmr.1926
  31. Zhao X, Yang B, Yu G, et al (2014). Polymorphisms in the vitamin D receptor (VDR) genes and skin cancer risk in European population: a meta-analysis. Arch Dermatol Res, 306, 545-53. https://doi.org/10.1007/s00403-014-1464-8
  32. Zhou L, Zhang X, Chen X, et al (2012). GC Glu416Asp and Thr420Lys polymorphisms contribute to gastrointestinal cancer susceptibility in a Chinese population. Int J Clin Exp Med, 5, 72-9.

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