Asian Pacific Journal of Cancer Prevention

  • 제16권9호
  • /
  • Pages.3881-3885
  • /
  • 2015
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Inhibition of Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet by Pleurotus eryngii (Eringi) and Hypsizygus marmoreus (Bunashimeji)

  • Kaneko, Takaaki (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) ;
  • Chihara, Takeshi (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) ;
  • Shimpo, Kan (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) ;
  • Beppu, Hidehiko (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) ;
  • Higashiguchi, Takashi (Department of Surgery & Palliative Medicine, School of Medicine, Fujita Health University) ;
  • Sonoda, Shigeru (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University)
  • 발행 : 2015.05.18
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Obesity markedly increases the risk of colorectal cancer. Recently, the preventive effects of edible mushrooms on triglyceride elevation and visceral fat accumulation have been reported. Here, the effects of Pleurotus eryngii (Eringi) and Hypsizygus marmoreus (Bunashimeji) on azoxymethane (AOM)-induced aberrant crypt foci (ACF; precancerous lesions) in the colorectums of mice fed a high-fat diet were examined. Eringi (ER) and Bunashimeji (BU) mushroom powder samples were used. Six-week-old male C57BL/6J mice received an intraperitoneal injection of AOM (10 mg/kg) once a week for two weeks, and were sacrificed and dissected at 6 weeks after the start of the experiment. After the initiation of the experiment, they received a normal diet (ND), high-fat diet (HFD), HFD + ER (1 or 5% of diet), or HFD + BU (1 or 5% of diet). As a result, body and fat weights were significantly lower in the 5% ER and BU groups than in the HFD group. Liver triglyceride levels were also significantly lower in the 5% ER and BU groups. Total liver cholesterol levels were significantly lower in the 5% ER group. The numbers of ACF (especially large ACF) showed strong inhibitory effects in both ER and BU groups. Measurement of the cell proliferation marker Ki-67 labeling index in the colonic mucosa demonstrated more significant suppression in both ER and BU groups than in the HFD group. These results suggest that the simultaneous intake of ER and BU may inhibit colorectal tumorigenesis in HFD-fed mice.

키워드

참고문헌

  1. Bardou M, Barkun AN, Martel M (2013). Obesity and colorectal cancer. Gut, 62, 933-47. https://doi.org/10.1136/gutjnl-2013-304701
  2. Calle EE, Kaaks R (2004). Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer, 4, 579-91. https://doi.org/10.1038/nrc1408
  3. Cancer Information Service (2015). Statistical information of cancers in different parts of body. http://ganjoho.jp/public/statistics/pub/statistics04.html (in Japanese). Accessed 1 March 2015.
  4. Edvardsson U, Ljungberg A, Linden D, et al (2006). PPAR${\alpha}$ activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes. J Lipid Res, 47, 329-40.
  5. Endo H, Higurashi T, Takahashi H, Nakajima A (2013). Obesity, life style-related diseases and colorectal cancer. Gastroenterol Endosc, 55, 3735-44.
  6. Endo H, Hosono K, Fujisawa T, et al (2009). Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions. Gut, 58, 1637-43. https://doi.org/10.1136/gut.2009.183624
  7. Guillamon E, Garcia-Lafuente A, Lozano M, et al (2010). Edible mushroom: role in the prevention of cardiovascular diseases. Fitoterapia, 81, 715-23. https://doi.org/10.1016/j.fitote.2010.06.005
  8. Huang XF, Xin X, McLennan P, Storlien L (2004). Role of fat amount and type in ameliorating diet-induced obesity: insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression. Diabetes Obes Metab, 6, 35-44. https://doi.org/10.1111/j.1463-1326.2004.00312.x
  9. Ikekawa T, Saitoh H, Feng W, et al (1992). Antitumor activity of Hypsizigus marmoreus. I. Antitumor activity of extracts and polysaccharides. Chem Pharm Bull, 40, 1954-7. https://doi.org/10.1248/cpb.40.1954
  10. Jayasuriya WJABN, Suresh TS, Thusitha D, et al (2012). Oral hypoglycemic activity of culinary-medicinal mushrooms Pleurotus ostreatus and P. cystidiosus (Higher Basidiomycetes) in normal and alloxan-induced diabetic Wistar rats. Int J Med Mushrooms, 14, 347-55. https://doi.org/10.1615/IntJMedMushr.v14.i4.20
  11. Jeong SC, Jeong YT, Yang BK, et al (2010). White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res, 30, 49-56. https://doi.org/10.1016/j.nutres.2009.12.003
  12. Kaneko T, Shimpo K, Chihara T, et al (2012). Inhibition of ENNG-induced pyloric stomach and small intestinal carcinogenesis in mice by high temperature- and pressure-treated garlic. Asian Pac J Cancer Prev, 13, 1983-8. https://doi.org/10.7314/APJCP.2012.13.5.1983
  13. Katsuki T, Hirata K, Ishikawa H, et al (2006). Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats. J Nutr, 136, 847s-51s.
  14. Lin S, Thomas TC, Storlien LH, Huang XF (2000). Development of high fat diet-induced obesity and leptin resistance in C57BL/6J mice. Int J Obes Relat Metab Disord, 24, 639-46. https://doi.org/10.1038/sj.ijo.0801209
  15. Matsuzawa T, Saitoh H, Sano M, et al (1998). Studies on antioxidant effect of Hypsizigus marmoreus. II. Effects of Hypsizigus marmoreus for antioxidant activities of tumor-bearing mice. Yakugaku Zasshi, 118, 476-81.
  16. Matsuzawa T, Sano M, Tomita I, Saitoh H, Ikekawa T (1997). Studies on antioxidant effect of Hypsizigus marmoreus. I. Effects of Hypsizigus mormoreus for antioxidant activities of mice plasma. Yakugaku Zasshi, 117, 623-8 (in Japanese).
  17. McLellan EA, Bird RP (1988). Aberrant crypts: potential preneoplastic lesions in the murine colon. Cancer Res, 48, 6187-92.
  18. Miyazaki S (2002). Obesity and risk factors. J Clin Sports Med, 19, 112-8 (in Japanese).
  19. Mizutani T, Inatomi S, Kurashima E, Tsuchida T (2008). Suppressive effect of Pleurotus eryngii extract on postprandial serum triacylglycerol elevation. Jpn Pharmacol Ther, 36, 817-23 (in Japanese).
  20. Mori K, Kobayashi C, Tomita T, Inatomi S, Ikeda M (2008). Antiatherosclerotic effect of the edible mushrooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipoprotein E-deficient mice. Nutr Res, 28, 335-42. https://doi.org/10.1016/j.nutres.2008.03.010
  21. Ohno N, Furukawa M, Miura NN, et al (2001). Antitumor ${\beta}$-glucan from the cultured fruit body of Agaricus blazei. Biol Pharm Bull, 24, 820-8. https://doi.org/10.1248/bpb.24.820
  22. Ohtsuki M, Umeshita K, Kokean Y, et al (2007). Suppressive effects of Bunashimeji (Hypsizigus marmoreus) on triacylglycerol accumulation in C57BL/6J mice. Nippon Shokuhin Kagaku Kogaku Kaishi, 54, 167-72 (in Japanese). https://doi.org/10.3136/nskkk.54.167
  23. Otake S, Takeda H, Suzuki Y, et al (2005). Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res, 11, 3642-6. https://doi.org/10.1158/1078-0432.CCR-04-1868
  24. Ren L, Perera C, Hemar Y (2012). Antitumor activity of mushroom polysaccharides: a review. Food Funct, 11, 1118-30.
  25. Sato M, Tokuji Y, Yoneyama S, et al (2013). Effect of dietary maitake (Grifola frondosa) mushrooms on plasma cholesterol and hepatic gene expression in cholesterol-fed mice. J Oleo Sci, 62, 1049-58. https://doi.org/10.5650/jos.62.1049
  26. Takahashi H, Takayama T, Yoneda K, et al (2009). Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population. Cancer Sci, 100, 29-32. https://doi.org/10.1111/j.1349-7006.2008.00994.x
  27. Ministry of Health, Labour and Welfare (2012). Vital statistics Japan. Available: http://www.mhlw.go.jp/english/database/db-hw/index.html. Accessed 28 July 2014.

피인용 문헌

  1. Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model vol.311, pp.4, 2016, https://doi.org/10.1152/ajpgi.00207.2016