Journal of the Korean Institute of Oriental Medical Informatics (대한한의정보학회지)
- Volume 21 Issue 1
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- Pages.14-22
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- 2015
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- 1598-4206(pISSN)
Quercetin Induces Mitochondrial Biogenesis via HO-1 Expression in HepG2 Cell
HepG2 cell에서 quercetin의 HO-1 발현을 통한 mitochondria의 생합성 유도 효과에 관한 연구
- Kang, Jaekoo (Dept. of Third Medicine, Professional Graduate School of Korean Medicine) ;
- Jang, Sang Chul (Dept. of Third Medicine, Professional Graduate School of Korean Medicine) ;
- Lee, Ki Seung (Detp. of Preventive Medicine, College of Korean Medicine, Wonkwang University) ;
- Kim, Jin Hee (Dept. of Third Medicine, Professional Graduate School of Korean Medicine) ;
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Chong, Myong Soo
(Detp. of Preventive Medicine, College of Korean Medicine, Wonkwang University)
- 강재구 (원광대학교 한의학전문대학원 제3의학과) ;
- 장상철 (원광대학교 한의학전문대학원 제3의학과) ;
- 이기승 (원광대학교 한의과대학 예방의학교실) ;
- 김진희 (원광대학교 한의학전문대학원 제3의학과) ;
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정명수
(원광대학교 한의과대학 예방의학교실)
- Published : 2015.06.30
Abstract
Flavonoids show diverse bioactivities, such as anti-oxidant, anti-cancer, anti-allergic, anti-inflammatory, and anti-viral. Quercetin is one of the flavonoids present in a wide range of plants, especially onions and consumed all over the world. Recently, it is known that quercetin induces mitochondrial biogenesis in vivo and in vitro. However, detail mechanism of these actions remains unknown. We investigated quercetin's effects on mitochondrial biogenesis in HepG2 cells, and determined the mechanisms involved. We found that quercetin treatment induced the expression of mitochondrial biogenesis activators,