Intestinal research

Korean Association for the Study of the Intestinal Diseases (대한장연구학회)
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Refractory Clostridium difficile Infection Cured With Fecal Microbiota Transplantation in Vancomycin-Resistant Enterococcus Colonized Patient

  • Jang, Mi-Ok (Department of Internal Medicine, Chonnam National University Medical School) ;
  • An, Jun Hwan (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Jung, Sook-In (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Park, Kyung-Hwa (Department of Internal Medicine, Chonnam National University Medical School)
  • Received : 2013.11.12
  • Accepted : 2014.04.04
  • Published : 2015.01.31
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Abstract

The rates and severity of Clostridium difficile infections, including pseudomembranous colitis, have increased markedly. However, there are few effective treatments for refractory or recurrent C. difficile infections and the outcomes are poor. Fecal microbiota transplantation is becoming increasingly accepted as an effective and safe intervention in patients with recurrent disease, likely due to the restoration of a disrupted microbiome. Cure rates of >90% are being consistently reported from multiple centers. We cured a case of severe refractory C. difficile infection with fecal microbiota transplantation in a patient colonized by vancomycin-resistant enterococcus.

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  12. Successful use of early, repeat fecal microbiota transplantation for initial treatment of severe, refractory Clostridioides difficile colitis vol.78, pp.15, 2015, https://doi.org/10.1093/ajhp/zxab161