Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
권호 표지
DOI QR코드

DOI QR Code

Correlation Between High-Sensitive Collimator and Quantitave Analysis in Lung Ventilation SPECT

폐 환기 SPECT에서 고감도 Collimator와 정량분석의 상관관계

  • Kim, Jung-Soo (Department of Radiological Technology, Dongnam Health University) ;
  • Kim, Sang-Hyun (Department of Diagnostic Radiology, Seoul National University Hospital)
  • 김정수 (동남보건대학교 방사선과) ;
  • 김상현 (서울대학교병원 영상의학과)
  • Received : 2015.04.28
  • Accepted : 2015.06.04
  • Published : 2015.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study investigated the correlation between the characteristics of collimator in accordance with the efficiency of detecting photon signals and the quantitative analysis of the lung function, thereby assessing the possibility of clinically applying high sensitivity lung ventilation SPECT. From March to May, 2014, 10 subjects in normal volunteers underwent an ultra high resolution, high resolution and high sensitivity collimator planar scan and SPECT. The experiment showed that compared with the collimator scan, the quantitative analysis results were significant (p=0.89), and compared to the high resolution collimator SPECT, the time was reduced by 4.9 fold. Therefore, the lung ventilation SPECT that had not been used due to an undermined effectiveness can offer usefulness when clinically applied if a high sensitivity collimator is used since the quality and quantity of information and the duration of scan time all offer an improvement.

본 연구는 광자 신호의 검출 효율에 따른 collimator의 특성과 폐기능 정량분석의 상관관계를 비교하여 고감도 collimator 폐 환기 SPECT의 임상적용 가능성을 평가하였다. 2014년 3월부터 5월까지 10명의 정상 성인을 대상으로 초고해상도, 고해상도, 고감도 3종류의 collimator를 이용하여 평면 스캔과 SPECT를 비교 실험하였다. 기존 검사방법인 고해상도 collimator 평면 스캔과 비교하여 정량분석 결과는 유의하였으며(p=0.89), 고해상도 collimator SPECT보다 4.9배의 시간이 단축되었다. 따라서 효용성 저하로 제한적으로 시행하였던 폐 환기 SPECT는 고감도 collimator를 이용하면 진단 정보의 양과 질, 검사시간의 단축 측면에서 효과적이므로 추후 임상적용에 유용할 것으로 사료된다.

Keywords

References

  1. H. Dirk Sostman, Paul D. Stein, Alexander Gottschalk, Fadi Matta, Russell Hull, MBBS, Larry Goodman, et al.: Acute pulmonary embolism : sensitivity and specificity of ventilation-perfusion scintigraphy in PIOPED II study. Radiology, 246(3), 941-946, 2008 https://doi.org/10.1148/radiol.2463070270
  2. Marie-Pierre Revel, StSphanie Cohen, Olivier Sanchez, Marie-Anne Collignon, Rokhaya Thiam, Alban Redheuil, Guy Meyer, et al.: Pulmonary embolism during pregnancy : diagnosis with lung scintigraphy or CT angiography? Radiology, 258(2), 590-598, 2011 https://doi.org/10.1148/radiol.10100986
  3. Susan Miles, Kerry M. Rogers, Paul Thomas, Barry Soans, John Attia, Christian Abel, Elizabeth Holt, Catherine A. D'Este, Michael J. Hensley: A comparison of single-photon emission CT lung scintigraphy and CT pulmonary angiography for the diagnosis of pulmonary embolism. Chest, 136(6), 1546-1553, 2009 https://doi.org/10.1378/chest.09-0361
  4. Pat Zanzonico, Micheal G. Stabin: Quantitative benefit-risk analysis of medical radiation exposures. Semin Nucl Med, 44(3), 210-214, 2014 https://doi.org/10.1053/j.semnuclmed.2014.03.010
  5. Malin Kjellberg, Karin Bjorkman, Malin Rohdin, Alejandro Sanchez-Crespo, Baldvin Jonsson: Bronchopulmonary dysplasia: Clinical grading in relation to ventilation/perfusion mismatch measured by single photon emission computed tomography. Pediatr Pulmonol, 48(12), 1206-1213, 2013 https://doi.org/10.1002/ppul.22751
  6. Chukwuemeka Onyedika, Joseph E. Glaser, Leonard M. Freeman: Pulmonary embolism: role of ventilationperfusion scintigraphy. Semin Nucl Med, 43(2), 82-87, 2013 https://doi.org/10.1053/j.semnuclmed.2012.11.002
  7. Stein PD., Freeman LM., Sostman HD., Goodman LR., Woodard PK., Naidich DP., Gottschalk A., Bailey DL., Matta F., Yaekoub AY., Hales CA., Hull RD., Leeper KV Jr., Tapson VF., Weg JG: SPECT in acute pulmonary embolism. J Nucl Med, 50(12), 1999-2007, 2009 https://doi.org/10.2967/jnumed.109.063958
  8. Pat Zanzonico: Principles of nuclear medicine imaging: planar, SPECT, PET, multi-modality, and autoradiography systems. Rad Research, 177(4), 349-364, 2012 https://doi.org/10.1667/RR2577.1
  9. Bajc M, Olsson CG, Olsson B, Palmer J, Jonson B: Diagnostic evaluation of planar and tomographic ventilation/perfusion lung images in patients with suspected pulmonary emboli. Clin Physiol Funct Imaging, 24(5), 249-256, 2004 https://doi.org/10.1111/j.1475-097X.2004.00546.x
  10. Alexandra Le Duc-Pennec, Pierre-Yves Le Roux, Jean Christophe Cornily, Morgan Jaffrelot, AurSlien Delluc, Luc de Saint-Martin, Philippe Guillo, GrSgoire Le Gal, Pierre-Yves Salaun, Christophe Leroyer: Diagnostic accuracy of single-photon emission tomography ventilation/perfusion lung Scan in the Diagnosis of Pulmonary Embolism. Chest, 141(2), 381-387, 2012 https://doi.org/10.1378/chest.11-0090
  11. Johan Petersson, Alejandro SSnchez-Crespo, Stig A. Larsson, Margareta Mure: Physiological imaging of the lung: single-photon-emission computed tomography (SPECT). J Applied Phys, 102(1), 468-476, 2007 https://doi.org/10.1152/japplphysiol.00732.2006
  12. Michel A. Meignan: Lung ventilation/perfusion SPECT: the right technique for hard times. J Nucl Med, 43(5), 648-651, 2002
  13. Paul J. Roach, Dale L. Bailey, Geoffrey P. Schembri: Reinventing ventilation/perfusion lung scanning with SPECT. Nucl Med Com, 29(12), 1023-1025, 2008 https://doi.org/10.1097/MNM.0b013e328315efa1
  14. Paul J. Roach, Geoffrey P. Schembri, Dale L. Bailey: V/Q scanning using SPECT and SPECT/CT. Nucl Med Com, 54(9), 1588-1596, 2013 https://doi.org/10.2967/jnumed.113.124602
  15. M. Bajc, J. B. Neilly, M. Miniati, C. Schuemichen, M. Meignan, B. Jonson: EANM guidelines for ventilation/perfusion scintigraphy. Eur J Nucl Med Mol Imaging, 36(9), 1528-1538, 2009 https://doi.org/10.1007/s00259-009-1169-y
  16. Pierre-Yves Le Roux, Xavier Palard, Philippe Robin, Aurelien Delluc, Ronan Abgral, Solene Querellou, Francis Couturaud, Gregoire Le Gal, Pierre-Yves Salaun: Safety of ventilation/perfusion single photon emission computed tomography for pulmonary embolism diagnosis. Eur J Nucl Med Mol Imaging, 41(10), 1957-1964. 2014 https://doi.org/10.1007/s00259-014-2763-1
  17. Jonas Jogi, Bjorn Jonson, Marie Ekberg, Marika Bajc: Ventilation-perfusion SPECT with 99mTc-DTPA versus technegas: A head-to-head study in obstructive and nonobstructive disease. J Nucl Med, 51(5), 735-741, 2010 https://doi.org/10.2967/jnumed.109.073957
  18. Bajc M, Olsson B, Palmer J, Jonson B: Ventilation/perfusion SPECT for diagnostics of pulmonary embolism in clinical practice. J Intern Med, 264(4), 379-387, 2008 https://doi.org/10.1111/j.1365-2796.2008.01980.x
  19. Sasaki Y, Imai T, Shinkai T, et al.: Estimation of regional lung function in interstitial pulmonary disease using 99mTc-technegas and 99mTc-MAA single-photon emission computed tomography. Eur J Nucl Med, 25(12), 1623-1629. 1998 https://doi.org/10.1007/s002590050340
  20. Blumenschein George R. Jr., Ciuleanu, Tudor, Robert Francisco, Groen Harry J. M., Usari, Tiziana, Ruiz-Garcia Ana Pharm, Tye Lesley, Chao Richard C., Juhasz Erzsebet: Sunitinib plus erlotinib for the treatment of advanced/metastatic non-small-cell lung cancer: a lead-in study. J Thorac Onc, 7(9), 1406-1416. 2012 https://doi.org/10.1097/JTO.0b013e31825cca1c
  21. Dale L. Bailey, Kathy P. Willowson: An evidence based review of quantitative SPECT imaging and potential clinical applications. J Nucl Med, 54(1), 83-89, 2013 https://doi.org/10.2967/jnumed.112.111476
  22. Laura K. Nason, Christopher M. Walker, Michael F. McNeeley, Wanaporn Burivong, Corinne L. Fligner, J. David Godwin: Imaging of the diaphragm: anatomy and function. Radio Graphics, 32(2), 51-70, 2012
  23. Daniel M. Adams, Scott M. Stevens, Scott C. Woller, R. Scott Evans, James F. Lloyd, Gregory L. Snow, Todd L. Lovelace, et al.: Adherence to PIOPED II investigator' recommendations for computed tomography pulmonary angiography. J Amc Med, 126(1), 36-42, 2013 https://doi.org/10.1016/j.amjmed.2012.05.028
  24. H. Drik Sostman, Massimo Miniati, Alexandra Gottschalk, Fadi Matta, Paul D. Stein, Massimo Pistolesi: Sensitivity and Specificity of Perfusion Scintigraphy Combined with Chest Radiography for Acute Pulmonary Embolism in PIOPED II. J Nucl Med, 49(11), 1741-1748, 2008 https://doi.org/10.2967/jnumed.108.052217
  25. Fessler HE, Talmor Ds: Should prone positioning be routinely used for lung protection during mechanical ventilation? Respir Care, 55(1), 88-99, 2010
  26. Mark T. Madsen: Recent advances in SPECT imaging, J Nucl Med., 48(4), 661-673, 2007 https://doi.org/10.2967/jnumed.106.032680
  27. Ryszkowski J, Noce TA, Vento JA: The clinical application of image fusion software to PET, SPECT, CT and MRI. Clin Nucl Med, 31(2), 114, 2006.
  28. Andreas K. Buck, Stephan Nekolla, Sibylle Ziegler, Ambros Beer, Bernd J. Krause, Ken Herrmann, Klemens Scheidhauer, Hans-Juergen Wester, Ernst J. Rummeny, et al.: SPECT/CT. J Nucl Med, 49(8), 1305-1319, 2008 https://doi.org/10.2967/jnumed.107.050195