Rapid Communication in Photoscience

Korean Society of Photoscience (한국광과학회)
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Generation of Demyelination through Use of M. leprae-specific phenolic glycolipid-1 (PGL-1)

  • Kim, Ji-Young (Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine) ;
  • Choi, Chang-Shik (Department of Food and Fermentation, Far East University) ;
  • Hong, Seong-Karp (Division of Bio and Health Sciences, Mokwon University)
  • Received : 2015.06.27
  • Accepted : 2015.06.29
  • Published : 2015.06.30
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Abstract

For myelination, Schwann cells and neuron cells from dorsal root ganglion (DRG) of rat embryos (E16) were cultured in vitro system. The purified DRG cells with anti-mitotic agents and purified Schwann cells were cocultured and then accomplished myelination processing. Treatment of M. leprae-specific phenolic glycolipid-1 (PGL-1) into this coculture system was performed and then accomplished demyelination. Therefore, we identified demyelination processing using antibody of myelin basic protein (MBP).

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References

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