References
- Kurosaki R, Muramatsu Y, Kato H, Araki T. Biochemical, behavioral, and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacol Biochem Behav 2004;78:143-53. https://doi.org/10.1016/j.pbb.2004.03.006
- Kanungo J, Zheng YL, Amin ND, Pant HC. Targeting Cdk5 activity in neuronal degeneration and regeneration. Cell Mol Neurobiol 2009;29:1073-80. https://doi.org/10.1007/s10571-009-9410-6
- Cruz JC, Tsai LH. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin Neurobiol 2004;14:390-4. https://doi.org/10.1016/j.conb.2004.05.002
- Cheung ZH, Gong K, Ip NY. Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J Neurosci 2008;28:4872-7. https://doi.org/10.1523/JNEUROSCI.0689-08.2008
- Zheng YL, Li BS, Kanungo J, Kesavapany S, Amin N, Grant P, Pant HC. Cdk5 modulation of mitogen-activated protein kinase signaling regulates neuronal survival. Mol Biol Cell 2007;18:404-13. https://doi.org/10.1091/mbc.e06-09-0851
- Choi KT. Botanical characteristics, pharmacological effects, and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 2008;29: 1109-18. https://doi.org/10.1111/j.1745-7254.2008.00869.x
- Cheng W, Wu D, Zuo Q, Wang Z, Fan W. Ginsenoside Rb1 prevents interleukin- 1 beta induced inflammation and apoptosis in human articular chondrocytes. Int Orthop 2013;37:2065-70. https://doi.org/10.1007/s00264-013-1990-6
- Kitts D, Hu C. Efficacy and safety of ginseng. Public Health Nutr 2000;3: 473-85.
- Cho IH. Effects of Panax ginseng in neurodegenerative diseases. J Ginseng Res 2012;36:342-53. https://doi.org/10.5142/jgr.2012.36.4.342
- Hu S, Han R, Mak S, Han Y. Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. J Ethnopharmacol 2011;135:34-42. https://doi.org/10.1016/j.jep.2011.02.017
- Van Kampen J, Robertson H, Hagg T, Drobitch R. Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease. Exp Neurol 2003;184:521-9. https://doi.org/10.1016/j.expneurol.2003.08.002
- Xu H, Jiang H, Wang J, Xie J. Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 upregulation and cellular iron uptake. Neuropharmacology 2010;58:488-94. https://doi.org/10.1016/j.neuropharm.2009.09.002
- Wang J, Xu HM, Yang HD, Du XX, Jiang H, Xie JX. Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins. Neurochem Int 2009;54:43-8. https://doi.org/10.1016/j.neuint.2008.10.003
- Lee JH, Lee HJ, Yang M, Moon C, Kim JC, Bae CS, Jo SK, Jang JS, Kim SH. Effect of Korean Red Ginseng on radiation-induced bone loss in C3H/HeN mice. J Ginseng Res 2013;37:435-41. https://doi.org/10.5142/jgr.2013.37.435
- Kim ST, Moon W, Chae Y, Kim YJ, Lee H, Park HJ. The effect of electroacupuncture for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced proteomic changes in the mouse striatum. J Physiol Sci 2010;60:27-34. https://doi.org/10.1007/s12576-009-0061-7
- Abe K, Taguchi K, Wasai T, Ren J, Utsunomiya I, Shinohara T, Miyatake T, Sano T. Biochemical and pathological study of endogenous 1-benzyl-1,2,3,4- tetrahydroisoquinoline-induced parkinsonism in the mouse. Brain Res 2001;907:134-8. https://doi.org/10.1016/S0006-8993(01)02573-2
- Hirsch EC, Faucheux BA. Iron metabolism and Parkinson's disease. Mov Disord 1998;13(Suppl. 1):39-45. https://doi.org/10.1002/mds.870130111
- Hirsch EC, Hunot S, Damier P, Faucheux B. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann Neurol 1998;44:S115-20. https://doi.org/10.1002/ana.410440717
- Meredith GE, Kang UJ. Behavioral models of Parkinson's disease in rodents: a new look at an old problem. Mov Disord 2006;21:1595-606. https://doi.org/10.1002/mds.21010
- Cheung ZH, Ip NY. Cdk5: a multifaceted kinase in neurodegenerative diseases. Trends Cell Biol 2012;22:169-75. https://doi.org/10.1016/j.tcb.2011.11.003
- Qu D, Rashidian J, Mount MP, Aleyasin H, Parsanejad M, Lira A, Haque E, Zhang Y, Callaghan S, Daigle M, et al. Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron 2007;55:37-52. https://doi.org/10.1016/j.neuron.2007.05.033
- Alvira D, Ferrer I, Gutierrez-Cuesta J, Garcia-Castro B, Pallas M, Camins A. Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease. Parkinsonism Relat Disord 2008;14:309-13. https://doi.org/10.1016/j.parkreldis.2007.09.005
- Czapski GA, Gassowska M, Wilkaniec A, Cieslik M, Adamczyk A. Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro. FEBS Lett 2013;587:3135-41. https://doi.org/10.1016/j.febslet.2013.07.053
- Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, et al. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 2003;100:13650-5. https://doi.org/10.1073/pnas.2232515100
- Kim SN, Doo AR, Park JY, Bae H, Chae Y, Shim I, Lee H, Moon W, Lee H, Park HJ. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PLoS One 2011;6:e27566. https://doi.org/10.1371/journal.pone.0027566
- Venderova K, Park DS. Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med June 27, 2012;2:a009365. http://dx.doi.org/10.1101/cshperspect.a009365.
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