References
- Frazier TH, Stocker AM, Kershner NA, Marsano LS, McClain CJ. Treatment of alcoholic liver disease. Therap Adv Gastroenterol 2011;4:63-81. https://doi.org/10.1177/1756283X10378925
- Gramenzi A, Caputo F, Biselli M, Kuria F, Loggi E, Andreone P, Bernardi M. Review article: alcoholic liver disease - pathophysiological aspects and risk factors. Aliment Pharmacol Ther 2006;24:1151-61. https://doi.org/10.1111/j.1365-2036.2006.03110.x
- Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology 2006;43: S63-74. https://doi.org/10.1002/hep.20957
- Lu Y, Cederbaum AI. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 2008;44:723-38. https://doi.org/10.1016/j.freeradbiomed.2007.11.004
- Morgan K, French SW, Morgan TR. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology 2002;36:122-34.
- Lu Y, Wu D, Wang X, Ward SC, Cederbaum AI. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med 2010;49:1406-16. https://doi.org/10.1016/j.freeradbiomed.2010.07.026
- Morimoto M, Hagbjork AL, Wan YJ, Fu PC, Clot P, Albano E, Ingelman- Sundberg M, French SW. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology 1995;21:1610-7.
- Morimoto M, Reitz RC, Morin RJ, Nguyen K, Ingelman-Sundberg M, French SW. CYP-2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet. J Nutr 1995;125:2953-64.
- Gouillon Z, Lucas D, Li J, Hagbjork AL, French BA, Fu P, Fang C, Ingelman- Sundberg M, Donohue Jr TM, French SW. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proc Soc Exp Biol Med 2000;224:302-8. https://doi.org/10.1046/j.1525-1373.2000.22435.x
- Purohit V, Gao B, Song BJ. Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 2009;33:191-205. https://doi.org/10.1111/j.1530-0277.2008.00827.x
- You M, Fischer M, Deeg MA, Crabb DW. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 2002;277:29342-7. https://doi.org/10.1074/jbc.M202411200
- Mandard S, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 2004;61:393-416. https://doi.org/10.1007/s00018-003-3216-3
- Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011;13:376-88. https://doi.org/10.1016/j.cmet.2011.03.009
- You M, Liang X, Ajmo JM, Ness GC. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. Am J Physiol Gastrointest Liver Physiol 2008;294:G892-8. https://doi.org/10.1152/ajpgi.00575.2007
- Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Hepatocytespecific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 2009;9:327-38. https://doi.org/10.1016/j.cmet.2009.02.006
- Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 2008;29: 1109-18. https://doi.org/10.1111/j.1745-7254.2008.00869.x
- Lu JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 2009;7:293-302. https://doi.org/10.2174/157016109788340767
- Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK, Kim CK, Park JH. Steaming of ginseng at high temperature enhances biological activity. J Nat Prod 2000;63:1702-4. https://doi.org/10.1021/np990152b
- Kasai R, Besso H, Tanaka O, Saruwatari Y, Fuwa T. Saponins of red ginseng. Chem Pharmaceut Bull 1983;31:2120-5. https://doi.org/10.1248/cpb.31.2120
- Kim YS, Kim YH, Noh JR, Cho ES, Park JH, Son HY. Protective effect of Korean Red Ginseng against aflatoxin B1-induced hepatotoxicity in rat. J Ginseng Res 2011;35:243-9. https://doi.org/10.5142/jgr.2011.35.2.243
- Gum SI, Cho MK. Korean Red Ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol. Liver Int 2013;33:1071-84. https://doi.org/10.1111/liv.12046
- Kwon YS, Jang KH. The effect of Korean red ginseng on liver regeneration after 70% hepatectomy in rats. J Vet Med Sci 2004;66:193-5. https://doi.org/10.1292/jvms.66.193
- KiSH, Yang JH, KuSK,KimSC, KimYW, Cho IJ. Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis. J Ginseng Res 2013;37:45-53. https://doi.org/10.5142/jgr.2013.37.45
- Ki SH, Choi JH, Kim CW, Kim SG. Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity. Chem Biol Interact 2007;169:80-90. https://doi.org/10.1016/j.cbi.2007.05.008
- Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B. Interleukin- 22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 2010;52:1291-300. https://doi.org/10.1002/hep.23837
- Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc 2013;8:627-37. https://doi.org/10.1038/nprot.2013.032
- Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR. Protein carbonylation in a murine model for early alcoholic liver disease. Chem Res Toxicol 2012;25:1012-21. https://doi.org/10.1021/tx300002q
- Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Am J Pathol 2005;166:1681-90. https://doi.org/10.1016/S0002-9440(10)62478-9
- Ishak KG, Zimmerman HJ, Ray MB. Alcoholic liver disease: pathologic, pathogenetic and clinical aspects. Alcohol Clin Exp Res 1991;15:45-66. https://doi.org/10.1111/j.1530-0277.1991.tb00518.x
- Altamirano J, Bataller R. Alcoholic liver disease: pathogenesis and new targets for therapy. Nat Rev Gastroenterol Hepatol 2011;8:491-501. https://doi.org/10.1038/nrgastro.2011.134
- Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011;141:1572-85. https://doi.org/10.1053/j.gastro.2011.09.002
- Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens Jr SM, You M. Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology 2014;146:801-11. https://doi.org/10.1053/j.gastro.2013.11.008
- Aroor AR, Shukla SD. Binge ethanol intake in chronically exposed rat liver decreases LDL-receptor and increases angiotensinogen gene expression. World J Hepatol 2011;3:250-5. https://doi.org/10.4254/wjh.v3.i9.250
- You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW. The role of AMPactivated protein kinase in the action of ethanol in the liver. Gastroenterology 2004;127:1798-808. https://doi.org/10.1053/j.gastro.2004.09.049
- Canto C, Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 2009;20:98-105. https://doi.org/10.1097/MOL.0b013e328328d0a4
- Shen Z, Liang X, Rogers CQ, Rideout D, You M. Involvement of adiponectin- SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 2010;298: G364-74. https://doi.org/10.1152/ajpgi.00456.2009
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