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Analysis of the Result of Korean Medicine Treatment for Female Subfertility Using Herbal Medicine, Acupuncture and Moxibustion Treatment

  • Jeong, Jae-Cheol (Department of Obstetrics & Gynecology, College of Korean Medicine, Dongguk University) ;
  • Choi, Min-Sun (Department of Obstetrics & Gynecology, College of Korean Medicine, Dongguk University) ;
  • Yoon, Sang-Ho (Department of Obstetrics & Gynecology, College of Medicine, Dongguk University) ;
  • Kim, Dong-Il (Department of Obstetrics & Gynecology, College of Korean Medicine, Dongguk University)
  • Received : 2014.12.25
  • Accepted : 2015.06.17
  • Published : 2015.06.30

Abstract

Objectives: To report on the result of infertility treatment with Korean medicine in clinical settings. Methods: This study was single arm, retrospective observational study. Analysis of the medical records on thirty four infertile women who were treated by acupuncture, moxibustion, herbal medicine(Jokyungjongoktang-gagambang, Sutaehwan-gagambang). Pregnancy rate(PR) and Live birth rate(LBR) were analyzed as the primary outcomes. Changes of AMH, FSH, LH, $E_2$, $P_4$, endometrial thickness, fat mass, and BMI were also analyzed as the secondary outcomes. Results: A total of 34 patients were treated in the traditional Korean medical clinic. Nine patients were dropped, and 25 subjects completed the final examination at the end of this treatment schedule. Five of 25 subjects conceived during treatment, reaching 20% PR and LBR was also 20%. Except for FSH level, the results of the remaining outcome measures, including LFT, showed no significant changes. No serious adverse event has been reported. Conclusion: Although no significant changes in bio-markers were observed, complex treatment using Korean medicine has shown effectiveness on women's infertility. In addition, the safety of the treatment has been verified.

Keywords

References

  1. Ministry of health and welfare of Korea, Medical college of Seoul national university. Analysis and evaluation of the national supporting program for infertility couples in 2008. 2009.
  2. Heo Jun. Trans. Committee of translating Dong-ui-bo-gam. Dong-ui-bo-gam. Seoul:Bubin publishers company. 1999.
  3. Jang GB. Gyeong-ak-jeon-seo, Bu-in-gyu. Trans. Lee TG. Seoul:Bubin publishers company. 1999.
  4. Jin JM. Bu-in-dae-jeon-yang-bang. Trans. Kim DI, et al. Seoul:Gwangsam publishers company. 2003.
  5. Zheng CH, Huang GY, Zhang MM, Wang W. Effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril. 2012;97:599-611. https://doi.org/10.1016/j.fertnstert.2011.12.007
  6. Reid K, Stuart K. Efficacty of traditional Chinese herbal medicine in the management of female infertility: A systematic review. Complement Ther Med. 2011;19:319-331. https://doi.org/10.1016/j.ctim.2011.09.003
  7. Hwang DY. Bangyakhappyeon. Seoul:Yeonglim publishers company. 2002.
  8. Lee HS, Cho KH, Kim TK, Kim CH, Ahn SJ, Lee EH, et al. Cho-kyung-jong-ok-tang, a traditional Korean herbal formula induces type2 shift in murine natural killer cell cytokine production. Jour Ethnopharmaco. 2011;134:281-287. https://doi.org/10.1016/j.jep.2010.12.021
  9. Min GH, Kim JY, Kim SB, Cho HB. Effects of Chokyungjongoktang on immune system by immobilization stress in C57BL/6J mice. The journal of oriental obstetrics and gynecology. 2004;17:46-60.
  10. Yang JM, Seo IB, Lee DN, Kim HJ. Effects of Jokyeongjonggk-Tang on the maturation of follicles and NGF expression in rats with estradiol valerate-induced polycystic ovaries. The journal of oriental obstetrics and gynecology. 2011;24:52-67.
  11. Bae JK, Kim GW. Effect of Jokyungjongoktang on the fluctuation of gonadotropin and sex hormone concentration in serum of women. The journal of dongguk oriental medicine. 1992;1: 15-54.
  12. Fan L. The clinical observation of added Shoutai pill on treating habitual abortion. Journal of new Chinese medicine. 2011;43: 81-83.
  13. Lai M, You Z, Ma H, Lei L, Lu F, He D, et al. Effects of Shoutai pills on expression of Th1/Th2 cytokine in maternal-fetal interface and pregnancy outcome. Zhongguo Zhong Yao Za Zhi. 2010;35:3065-3068.
  14. NG EH, So WS, Gao J, Wong YY, Ho PC. The role of acupuncture in the management of subfertility. Fertil Steril. 2008;09:1-13.
  15. Choi JK, Sin YW, Jung JH, Yu DR. Effect of Sutaehwan on immune response in pregnant BALB/C mice. The journal of oriental obstetrics and gynecology. 2003;16:87-97.
  16. Millheiser LS, Helmer AE, Quintero RB, Westphal LM, Milki AA, Lathi RB. Is infertility a risk factor for female sexual dysfunction? A case-control study. Fertil Steril. 2010;94:2022- 2025. https://doi.org/10.1016/j.fertnstert.2010.01.037
  17. Shindel AW, Nelson CJ, Naughton CK, Ohebshalom M, Mulhall JP. Sexual function and quality of life in the male partner of infertile couples: prevalence and correlates of dysfunction. J Urol. 2008;179:1056-1059. https://doi.org/10.1016/j.juro.2007.10.069
  18. van Rooij IA, Broekmans FJ, Scheffer GJ, Looman CW, Habbema JD, de Jong FH, et al. Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril. 2005;83:979-987. https://doi.org/10.1016/j.fertnstert.2004.11.029

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