Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Lactobacillus rhamnosus GG Reverses Insulin Resistance but Does Not Block Its Onset in Diet-Induced Obese Mice

  • Park, Kun-Young (School of Life Science, Handong Global University) ;
  • Kim, Bobae (School of Life Science, Handong Global University) ;
  • Hyun, Chang-Kee (School of Life Science, Handong Global University)
  • Received : 2014.09.05
  • Accepted : 2014.11.25
  • Published : 2015.05.28
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Abstract

Recently, Lactobacillus rhamnosus GG (LGG) was shown to exert insulin-sensitizing and adiposity-reducing effects in high-fat (HF) diet-fed mice. In the present study, we observed that the effects were correlated with the extent of dysbiosis induced by HF diet feeding before LGG administration. LGG-treated mice were protected from HF diet-induced adiposity and/or insulin resistance when LGG was treated after, not along with, HF diet feeding. Results indicate that, under HF dietary condition, supplemented LGG reverses insulin resistance, but does not block its onset.

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References

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