DOI QR코드

DOI QR Code

항 GD1b IgG 단일 항체와 관련된 길랭-바레 증후군으로 발현된 편평상피세포 폐암 증례

A Case of Squamous Cell Lung Cancer Representing as Guillain-Barre Syndrome Associated with Monospecific Anti-GD1b IgG

  • 김예신 (강원대학교 의과대학 신경과학교실) ;
  • 김성헌 (강원대학교 의과대학 신경과학교실)
  • Kim, Yeshin (Department of Neurology, Kangwon National University School of Medicine) ;
  • Kim, Seongheon (Department of Neurology, Kangwon National University School of Medicine)
  • 투고 : 2014.11.26
  • 심사 : 2015.06.03
  • 발행 : 2015.06.30

초록

We report a case with squamous cell lung cancer with concomitant Guillain-Barre syndrome (GBS) as a paraneoplastic syndrome. A 67-year-old patient who was previously diagnosed as metastatic squamous cell lung cancer developed mild symmetrical weakness, paresthesia and sensory ataxia. Nerve conduction study showed sensorimotor polyneuropathy. Analysis of cerebrospinal fluid showed high tilter for monospecific anti-GD1b IgG antibody without onconeuronal antibodies. After treatment with intravenous immunoglobulin, the patient's symptoms improved.

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참고문헌

  1. Hughes RA, Cornblath DR. Guillain-Barre syndrome. Lancet 2005;366:1653-1666. https://doi.org/10.1016/S0140-6736(05)67665-9
  2. Rudnicki SA, Dalmau J. Paraneoplastic syndromes of the peripheral nerves. Curr Opin Neurol 2005;18:598-603. https://doi.org/10.1097/01.wco.0000173462.17135.ee
  3. Graus F, Delattre J, Antoine J, Dalmau J, Giometto B, Grisold W, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 2004;75:1135-1140. https://doi.org/10.1136/jnnp.2003.034447
  4. Vigliani M-C, Magistrello M, Polo P, Mutani R, Chio A. Risk of cancer in patients with Guillain-Barre syndrome (GBS). J Neurol 2004;251:321-326. https://doi.org/10.1007/s00415-004-0317-3
  5. Cicero G, Fulfaro F, Caraceni A, Arcara C, Badalamenti G, Intrivici C, et al. A case of guillain-barre syndrome in a patient with non small cell lung cancer treated with chemotherapy. J Chemother 2006;18:325-327. https://doi.org/10.1179/joc.2006.18.3.325
  6. Navani V, Webster D, Williams SK, Agranoff D. Guillain-Barre syndrome as a paraneoplastic manifestation of disseminated squamous cell carcinoma. BMJ Case Rep 2013;2013. pii: bcr2013009700.
  7. Naveed S, Okoli K, Hollingsworth J, Kasmani R. Guillain-Barre syndrome as a paraneoplastic manifestation of small-cell carcinoma of lung. South Med J 2010;103:156-158. https://doi.org/10.1097/SMJ.0b013e3181bfd2c0
  8. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J Peripher Nerv Syst 2008;13:27-46. https://doi.org/10.1111/j.1529-8027.2008.00156.x
  9. Kusunoki S, Hitoshi S, Kaida KI, Arita M, Kanazawa I. Monospecific anti-GD1b IgG is required to induce rabbit ataxic neuropathy. Ann Neurol 1999;45:400-403. https://doi.org/10.1002/1531-8249(199903)45:3<400::AID-ANA19>3.0.CO;2-Y
  10. Miyazaki T, Kusunoki S, Kaida K, Shiina M, Kanazawa I. Guillain-Barre syndrome associated with IgG monospecific to ganglioside GD1b. Neurology 2001;56:1227-1229. https://doi.org/10.1212/WNL.56.9.1227