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Human Papillomavirus Distribution among Women in Western Shandong Province, East China using Reverse Blot Hybridization Assay

  • Lee, Dongsup (Department of Clinical Laboratory Science, Hyejeon College) ;
  • Kim, Geehyuk (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
  • Kim, Sunghyun (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Park, Sunyoung (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
  • Wang, Hye-young (Optipham M&D, Inc., Wonju Eco Environmental Technology Center) ;
  • Park, Sangjung (Department of Clinical Laboratory Science, College of Medical Science, Daegu Haany University) ;
  • Han, Lin (Department of Pathology, Liaocheng School of Clinical Medicine, Taishan Medical University) ;
  • Yubo, Ren (Department of Pathology, Liaocheng School of Clinical Medicine, Taishan Medical University) ;
  • Li, Yingxue (Department of Pathology, Liaocheng School of Clinical Medicine, Taishan Medical University) ;
  • Park, Kwang Hwa (Department of Pathology, Yonsei University Wonju College of Medicine) ;
  • Lee, Hyeyoung (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
  • 투고 : 2015.05.19
  • 심사 : 2015.06.22
  • 발행 : 2015.06.30

초록

Cervical cancer is the third most common cancer in women worldwide and there is a significant association between human papillomavirus (HPV) infection and cervical cancer. Certain HPV groups, labeled high-risk (HR) HPV groups, are strongly associated with malignancies of the human cervix. HPV prevalence and genotype distribution were analyzed using the REBA $HPV-ID^{(R)}$ (YD Diagnostics, Yongin, Korea) assay based on the reverse blot hybridization assay (REBA) with a total of 324 liquid-based cytology samples from women in Western Shandong Province, East China and results were compared with cytological diagnosis. Most of the HPV genotypes that were detected in high-grade cervical lesions were HR-HPV genotypes such as HPV 16, 18, 33, 53, and 58. The prevalence of these HR-HPV genotypes increased in high-grade cervical lesions. However, from low- to high-grade cervical lesions, the ability to detect LR-HPV genotypes decreased. Additionally, in general, the single HPV genotype infection rate increases in proportion to the severity of the lesion. The study findings suggest that a currently available preventive vaccine against HPV 16 and 18 may have limited effectiveness for prevention of all HPV infection in this province. Finally, based on these findings, these data could guide national or regional vaccination programs in the Western Shandong Province of East China to substantially reduce the burden of cervical lesions.

키워드

참고문헌

  1. Agarossi A, Ferrazzi E, Parazzini F, Perno CF, Ghisoni L. Prevalence and type distribution of high-risk human papillomavirus infection in women undergoing voluntary cervical cancer screening in Italy. J Med Virol. 2009. 81: 529-535. https://doi.org/10.1002/jmv.21347
  2. Bao YP, Li N, Smith JS, Qiao YL. Human papillomavirus type distribution in women from Asia: a meta-analysis. Int J Gynecol Cancer. 2008. 18: 71-79
  3. Bosch FX, Burchell AN, Schiffman M, Giuliano AR, de Sanjose S, Bruni L, Tortolero-Luna G, Kjaer SK, Munoz N. Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia. Vaccine. 2008. Suppl 10: K1-16.
  4. Bosch FX, de Sanjose S. Chapter 1: human papillomavirus and cervical cancer - burden and assessment of causality. J Natl Cancer Inst Monogr. 2003. 31: 3-13.
  5. Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V. A review of human carcinogens-part B: biological agents. Lancet Oncol. 2009. 10: 321-322. https://doi.org/10.1016/S1470-2045(09)70096-8
  6. Ding X, Liu Z, Su J, Yan D, Sun W, Zeng Z. Human papillomavirus type-specific prevalence in women referred for colposcopic examination in Beijing. J Med Virol. 2014. 86: 1937-1943. https://doi.org/10.1002/jmv.24044
  7. Dunne EF, Unger ER, Sternberg M, McQuillan G, Swan DC, Patel SS, Markowitz LE. Prevalence of HPV infection among females in the United States. JAMA. 2007. 297: 813-819. https://doi.org/10.1001/jama.297.8.813
  8. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int J Cancer. 2010. 127: 2893-2917. https://doi.org/10.1002/ijc.25516
  9. Hu SY, Hong Y, Zhao FH, Lewkowitz AK, Chen F, Zhang WH, Pan QJ, Zhang X, Fei C, Li H, Qiao YL. Prevalence of HPV infection and cervical intraepithelial neoplasia and attitudes towards HPV vaccination among Chinese women aged 18-25 in Jiangsu province. Chin J Cancer Res. 2011. 23: 25-32. https://doi.org/10.1007/s11670-011-0025-3
  10. Kim S, Lee D, Park S, Kim TU, Jeon BY, Park KH, Lee H. REBA HPV-ID$^{(R)}$ for efficient genotyping of human papillomavirus in clinical samples from Korean patients. J Med Virol. 2012a. 84: 1248-1253. https://doi.org/10.1002/jmv.23334
  11. Kim S, Lee D, Kim Y, Kim G, Park S, Choi Y, Kim TU, Park KW, Lee H. Clinical evaluation of human papillomavirus DNA genotyping assay to diagnose women cervical cancer. J Exp Biomed Sci. 2012b. 18: 123-130.
  12. Liu XX, Fan XL, Yu YP, Ji L, Yan J, Sun AH. Human papillomavirus prevalence and type-distribution among women in Zhejiang province, southeast china: across-sectional study. BMC Infectious Diseases. 2014. 14: 708-714. https://doi.org/10.1186/s12879-014-0708-8
  13. Okadome M1, Saito T, Tanaka H, Nogawa T, Furuta R, Watanabe K, Kita T, Yamamoto K, Mikami M, Takizawa K. Potential impact of combined high- and low-risk human papillomavirus infection on the progression of cervical intraepithelial neoplasia 2. J Obstet Gynaecol Res. 2014. 40: 561-569. https://doi.org/10.1111/jog.12202
  14. Sun B, He J, Chen X, He M, He Z, Wang Y, Shang Q, Yu L, Wei L. Prevalence and genotype distribution of human papillomavirus infection in harbin, Northeast China. Arch Virol. 2014. 159: 1027-1032. https://doi.org/10.1007/s00705-013-1886-1
  15. Zhao FH, Lewkowitz AK, Hu SY, Chen F, Li LY, Zhang QM, Wu RF, Li CQ, Wei LH, Xu AD, Zhang WH. Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: a pooled analysis of 17 population-based studies. Int J Cancer. 2012. 131: 2929-2938. https://doi.org/10.1002/ijc.27571