Biomaterials and Biomechanics in Bioengineering

  • 제2권2호
  • /
  • Pages.71-84
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  • 2015
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  • 2465-9835(pISSN)
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  • 2465-9959(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

A novel low-profile flow sensor for monitoring of hemodynamics in cerebral aneurysm

  • Chen, Yanfei (Department of Industrial Engineering, University of Pittsburgh) ;
  • Jankowitz, Brian T. (Department of Neurological Surgery, University of Pittsburgh Medical Center) ;
  • Cho, Sung Kwon (Department of Mechanical Engineering and Materials Science, University of Pittsburgh) ;
  • Yeo, Woon-Hong (Department of Mechanical and Nuclear Engineering, Center for Rehabilitation Science and Engineering, Virginia Commonwealth University) ;
  • Chun, Youngjae (Department of Industrial Engineering, University of Pittsburgh)
  • 투고 : 2015.03.14
  • 심사 : 2015.04.25
  • 발행 : 2015.06.25
⟨ 이전 논문 다음 논문 ⟩

초록

A low-profile flow sensor has been designed, fabricated, and characterized to demonstrate the feasibility for monitoring hemodynamics in cerebral aneurysm. The prototype device is composed of three micro-membranes ($500-{\mu}m$-thick polyurethane film with $6-{\mu}m$-thick layers of nitinol above and below). A novel super-hydrophilic surface treatment offers excellent hemocompatibility for the thin nitinol electrode. A computational study of the deformable mechanics optimizes the design of the flow sensor and the analysis of computational fluid dynamics estimates the flow and pressure profiles within the simulated aneurysm sac. Experimental studies demonstrate the feasibility of the device to monitor intra-aneurysmal hemodynamics in a blood vessel. The mechanical compression test shows the linear relationship between the applied force and the measured capacitance change. Analytical calculation of the resonant frequency shift due to the compression force agrees well with the experimental results. The results have the potential to address important unmet needs in wireless monitoring of intra-aneurysm hemodynamic quiescence.

키워드

과제정보

연구 과제 주관 기관 : American Heart Association

참고문헌

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피인용 문헌

  1. Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics vol.12, pp.8, 2015, https://doi.org/10.1021/acsnano.8b04689