DOI QR코드

DOI QR Code

A novel low-profile flow sensor for monitoring of hemodynamics in cerebral aneurysm

  • Chen, Yanfei (Department of Industrial Engineering, University of Pittsburgh) ;
  • Jankowitz, Brian T. (Department of Neurological Surgery, University of Pittsburgh Medical Center) ;
  • Cho, Sung Kwon (Department of Mechanical Engineering and Materials Science, University of Pittsburgh) ;
  • Yeo, Woon-Hong (Department of Mechanical and Nuclear Engineering, Center for Rehabilitation Science and Engineering, Virginia Commonwealth University) ;
  • Chun, Youngjae (Department of Industrial Engineering, University of Pittsburgh)
  • 투고 : 2015.03.14
  • 심사 : 2015.04.25
  • 발행 : 2015.06.25

초록

A low-profile flow sensor has been designed, fabricated, and characterized to demonstrate the feasibility for monitoring hemodynamics in cerebral aneurysm. The prototype device is composed of three micro-membranes ($500-{\mu}m$-thick polyurethane film with $6-{\mu}m$-thick layers of nitinol above and below). A novel super-hydrophilic surface treatment offers excellent hemocompatibility for the thin nitinol electrode. A computational study of the deformable mechanics optimizes the design of the flow sensor and the analysis of computational fluid dynamics estimates the flow and pressure profiles within the simulated aneurysm sac. Experimental studies demonstrate the feasibility of the device to monitor intra-aneurysmal hemodynamics in a blood vessel. The mechanical compression test shows the linear relationship between the applied force and the measured capacitance change. Analytical calculation of the resonant frequency shift due to the compression force agrees well with the experimental results. The results have the potential to address important unmet needs in wireless monitoring of intra-aneurysm hemodynamic quiescence.

키워드

과제정보

연구 과제 주관 기관 : American Heart Association

참고문헌

  1. Babiker, M.H., Gonzalez, L.F., Albuquerque, F., Collins, D., Elvikis, A. and Frakes, D.H. (2010), "Quantitative effects of coil packing density on cerebral aneurysm fluid dynamics: an in vitro steady flow study", Ann. Biomed. Eng., 38(7), 2293-2301. https://doi.org/10.1007/s10439-010-9995-4
  2. Brisman, J.L., Song, J.K. and Newell, D.W. (2006), "Cerebral aneurysms", New England J. Med., 355(9), 928-939. https://doi.org/10.1056/NEJMra052760
  3. Boecher-Schwarz, H.G., Ringel, K., Kopacz, L., Heimann, A. and Kempski, O. (2000), "Ex vivo study of the physical effect of coils on pressure and flow dynamics in experimental aneurysms", Am. J. Neuroradiol., 21(8), 1532-1536.
  4. Canton, G., Levy, D.I. and Lasheras, J.C. (2005), "Changes in the intraaneurysmal pressure due to hydrocoil embolization", Am. J. Neuroradiol., 26(4), 904-907.
  5. Chun, Y., Hur, S.C., Kealey, C.P., Levi, D.S., Mohanchandra, K.P., Carlo, D.D., Eldredge, J.D., Vinuela, F. and Carman, G.P. (2011), "Intra-aneurysmal flow reductions in a thin film nitinol flow diverter", Smart Mater. Struct., 20(5), 055021. https://doi.org/10.1088/0964-1726/20/5/055021
  6. Chun, Y., Levi, D.S., Mohanchandra, K. and Carman, G.P. (2009), "Superhydrophilic surface treatment for thin film nitinol vascular applications", Mater. Sci. Eng.: C, 29(8), 2436-2441. https://doi.org/10.1016/j.msec.2009.07.004
  7. Dias, N.V., Ivancev, K., Malina, M., Hinnen, J.W., Visser, M., Lindblad, B. and Sonesson, B. (2004), "Direct intra-aneurysm sac pressure measurement using tip-pressure sensors: in vivo and in vitro evaluation", J. Vas. Surg., 40(4), 711-716. https://doi.org/10.1016/j.jvs.2004.07.045
  8. Huang, X., Liu, Y., Cheng, H., Shin, W., Fan, J., Liu, Z., Lu, C., Kong, G., Chen, K., Patnaik, D., Lee, S., Hage-Ali, S., Huang, Y. and Rogers, J.A. (2014), "Materials and designs for wireless epidermal sensors of hydration and strain", Adv. Func. Mater., 24(25), 3846. https://doi.org/10.1002/adfm.201303886
  9. Ellozy, S.H., Carroccio, A., Lookstein, R.A., Minor, M.E., Sheahan, C.M., Juta, J., Cha, A., Valenzuela, R., Addis, M.D., Jacobs, T.S. et al. (2004), "First experience in human beings with a permanently implantable intrasac pressure transducer for monitoring endovascular repair of abdominal aortic aneurysms", J. Vas. Surg., 40(3), 405-412. https://doi.org/10.1016/j.jvs.2004.06.027
  10. Fan, J., Yeo, W.H., Su, Y., Hattori, Y., Lee, W., Jung, S., Cheng, H., Zhang, Y., Liu, Z., Falgout,L., Bajema, M., Coleman, T., Gregoire, D., Larson, R., Huang, Y. and Rogers, J. A. (2014), "Fractal design concepts for stretchable electronics", Nature Commun., 5, 3266.
  11. Go, A.S., Moza_arian, D., Roger, V.L., Benjamin, E.J., Berry, J.D., Borden, W.B., Bravata, D.M., Dai, S., Ford, E.S., Fox, C.S. et al. (2013), "Heart disease and stroke statistics-2013 update: a report from the American Heart Association", Circulation, 127(1), e6-e245. https://doi.org/10.1161/CIR.0b013e31828124ad
  12. Groden, C., Laudan, J., Gatchell, S. and Zeumer, H. (2001), "Three-dimensional pulsatile flow simulation before and after endovascular coil embolization of a terminal cerebral aneurysm", J. Cerebral Blood Flow Metabol., 21(12), 1464-1471. https://doi.org/10.1097/00004647-200112000-00011
  13. Juvela, S., Poussa, K., Lehto, H. and Porras, M. (2013), "Natural history of unruptured intracranial aneurysms a long-term follow-up study", Stroke, 44(9), 2414-2421. https://doi.org/10.1161/STROKEAHA.113.001838
  14. Kenichi, T. and Gianchandani, Y.B. (2008), "A micromachined capacitive pressure sensor using a cavityless structure with bulk-metal/elastomer layers and its wireless telemetry application", Sensors, 8(4), 2317-2330. https://doi.org/10.3390/s8042317
  15. Lam, A.K., Ko, M.W., Leung, L.K., Kwok, J.C., Yuen, M.M. and Lam, D.C., "Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant", In Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE.
  16. Molyneux, A.J., Kerr, R.S., Yu, L.M., Clarke, M., Sneade, M., Yarnold, J.A. and Sandercock, P. (2005), "International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of e_ects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion", Lancet, 366(9488), 809-817. https://doi.org/10.1016/S0140-6736(05)67214-5
  17. Morales, H.G., Kim, M., Villa-Uriol, M.C., Diaz, E.V. and Frangi, A.F. (2009), "Inuence of coil packing rate and configuration on intracranial aneurysm hemodynamics", In World Congress on Medical Physics and Biomedical Engineering, Munich, Germany.
  18. Ohki, T., Ouriel, K., Silveira, P.G., Katzen, B., White, R., Criado, F. and Diethrich, E. (2007), "Initial results of wireless pressure sensing for endovascular aneurysm repair: the APEX trial-acute pressure measurement to confirm aneurysm sac exclusion", J. Vas. Surg., 45(2), 236-242. https://doi.org/10.1016/j.jvs.2006.09.060
  19. Raymond, J., Guilbert, F., Weill, A., Georganos, S.A., Juravsky, L., Lambert, A., Lamoureux, J., Chagnon, M. and Roy, D. (2003), "Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils", Stroke, 34(6), 1398-1403. https://doi.org/10.1161/01.STR.0000073841.88563.E9
  20. Rinkel, G.J., Djibuti, M., Algra, A. and Van Gijn, J. (1998), "Prevalence and risk of rupture of intracranial aneurysms a systematic review", Stroke, 29(1), 251-256. https://doi.org/10.1161/01.STR.29.1.251
  21. Sorteberg, A., Sorteberg, W., Turk, A.S., Rappe, A., Nakstad, P.H. and Strother, C.M. (2001), "Effect of Guglielmi detachable coil placement on intraaneurysmal pressure: experimental study in canines", Am. J. Neuroradiol., 22(9), 1750-1756.
  22. Szycher, M. (2012), Szycher's Handbook of Polyurethanes, Second Edition, CRC Press.
  23. Tulloch, A.W., Chun, Y., Levi, D.S., Mohanchandra, K.P., Carman, G.P., Lawrence, P.F. and Rigberg, D. A. (2011), "Super hydrophilic thin film nitinol demonstrates reduced platelet adhesion compared with commercially available endograft materials", J. Surg. Res., 171(1), 317-322. https://doi.org/10.1016/j.jss.2010.01.014
  24. Vlak, M.H., Algra, A., Brandenburg, R. and Rinkel, G.J. (2011), "Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis", Lancet Neurol., 10(7), 626-636. https://doi.org/10.1016/S1474-4422(11)70109-0
  25. Wardlaw, J.M. and White, P.M. (2000), "The detection and management of unruptured intracranial aneurysms", Brain, 123(2), 205-221. https://doi.org/10.1093/brain/123.2.205

피인용 문헌

  1. Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics vol.12, pp.8, 2015, https://doi.org/10.1021/acsnano.8b04689