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알코올성 지방간 환자에 있어 전침 치료의 효과: 무작위 배정 대조군 연구

The Effects of Electroacupuncture for Treatment of Patients with Non-Alcoholic Fatty Liver Disease: Prospective Randomized Controlled Study

  • 이창형 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 김병석 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 최애련 (대구한의대학교 한의과대학 사상체질과학교실) ;
  • 김경순 (대구한의대학교 한의과대학 내과학교실) ;
  • 곽민아 (대구한의대학교 한의과대학 내과학교실) ;
  • 김승모 (대구한의대학교 한의과대학 내과학교실)
  • Lee, Chang-Hyeong (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Kim, Byung-Seok (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Choi, Ae-Ryun (Department of Sasang Constitutional Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Kyung-Soon (Department of Internal Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Kwak, Min-A (Department of Internal Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Seung-Mo (Department of Internal Medicine, College of Korean Medicine, Daegu Haany University)
  • 투고 : 2015.05.07
  • 심사 : 2015.06.08
  • 발행 : 2015.06.30

초록

Objectives: The aim of this study was to evaluate the effectiveness and safety of electroacupuncture for non-alcoholic fatty liver disease (NAFLD). Methods: A randomized, controlled pilot trial was conducted. Twenty-two participants were randomized into one of the two groups: an acupuncture group (n=11) and wait-list group (n=11). The treatment group received 8 sessions of electroacupuncture over 8 weeks. Twenty points (CV4, CV12, both LR14, GB26, ST25, ST34, ST40, ST36, SP4, SP6, LR3) were selected for needling. The control group did not receive acupuncture treatment during study period and followup were done in the 4th and 8th weeks after randomization in both groups. The primary outcome was body fat computed tomography and the secondary outcomes included blood test (aspartate aminotransferase, alanine transferase, triglyceride, total cholesterol, high density lipoproteincholesterol, low density lipoprotein-cholesterol, blood sugar test, ${\gamma}$-guanosine triphosphate) and body composition test (body mass index, weight, body fat mass, body fat rate, waist hip ratio). Safety was assessed at every visit. Results: There was no significant differences in between the experimental group and control group. There were no adverse events. Conclusions: The results suggest that In patients with NAFLD, electroacupuncture treatment did not induce worsening of liver disease and liver function, but it was no improvement symptoms of fatty liver. Study of herb medicine treatments and other acupuncture therapy of NAFLD are required later.

키워드

참고문헌

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