Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Attenuation Effect of Chamaecyparis obtusa Leaf Essential Oils on Airway Hyperresponsiveness and Airway Inflammation in Ovalbumin-Induced Murine Asthma Model

Ovalbumin으로 유도된 마우스 천식 모델에서 편백나무 잎 정유성분에 의한 기도과민성과 기도염증의 완화 효과

  • Kim, Seong Kyeom (Department of Industrial Plant Science & Technology, Chungbuk National University) ;
  • Lee, Seung Min (Department of Industrial Plant Science & Technology, Chungbuk National University) ;
  • Lim, Heung Bin (Department of Industrial Plant Science & Technology, Chungbuk National University)
  • 김성겸 (충북대학교 농업생명환경대학 특용식물학과) ;
  • 이승민 (충북대학교 농업생명환경대학 특용식물학과) ;
  • 임흥빈 (충북대학교 농업생명환경대학 특용식물학과)
  • Received : 2015.03.16
  • Accepted : 2015.06.06
  • Published : 2015.06.30
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Abstract

In this study, essential oils were extracted from the leaf of Chamaecyparis obtusa (CLEO), indigenous to Korea, CLEO constituents were analysed, and the effects of CLEO on airway hyperresponsiveness (AHR) and airway inflammation (AI) were investigated in Ovalbumin (OVA)-induced asthma mouse model. Terpenoid components among identified CLEO constituents made up more than 80%. The CLEO-treated group in comparison to the control group showed reduced AHR, the decrease of eosinophil number in the bronchoalveolar lavage fluid (BALF), reduced specific anti-OVA IgE level in the serum, and a significant reduction in Th2 cytokines levels in the BALF with concentration. We concluded that CLEO have an alleviating effect on asthma-like symptoms such as AHR and AI. Further studies about antiasthmatic effect are necessary on the focus of single component of CLEO.

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References

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