Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Rosa multiflora and Rosa multiflora Complex on Lipid Content in Rats Fed a High-Fat·High-Cholesterol Diet

찔레꽃 및 찔레꽃 복합물 추출물이 고지방·고콜레스테롤 식이 흰쥐의 지질 함량 개선에 미치는 영향

  • Choi, Jeong-Hwa (Department of Food Nutrition, International University of Korea) ;
  • Baek, Ji-Yun (Department of Food Nutrition, International University of Korea) ;
  • Choi, Hee-Jin (Department of Food Nutrition, International University of Korea)
  • 최정화 (한국국제대학교 식품영양학과) ;
  • 백지윤 (한국국제대학교 식품영양학과) ;
  • 최희진 (한국국제대학교 식품영양학과)
  • Received : 2015.03.02
  • Accepted : 2015.04.06
  • Published : 2015.06.30
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Abstract

This study was conducted to investigate the effects of water extract from Rosa multiflora and Rosa multiflora complex on lipid metabolism in rats fed a high cholesterol diet. Experimental rats were divided into four groups, which were composed of normal diet group (N group), high cholesterol diet group (HF group), high cholesterol and 5% Rosa multiflora diet group (HR group), and high cholesterol and Rosa multiflora complex diet group (HRC group). Rosa multiflora complex is composed of Duchesnea chrysantha, Salvia plebeia R. BR., and Sasa borealis. The serum triglyceride (TG) content of the HF group was significantly higher than that of the N group, whereas that of the HRC group was significantly lower. Serum high-density lipoprotein-cholesterol contents of the HR and HRC groups were significantly higher than that of the HF group. The serum total cholesterol and low-density lipoprotein- cholesterol contents of the HF group were significantly higher than those of the N group, and especially the atherogenic index of the HRC group was significantly reduced compared to the HF group. The liver TG and total cholesterol contents of the HF group were significantly increased compared to the normal diet group, while those of the HR and HRC groups were significantly decreased compared to the HF group. Fecal total lipid and total cholesterol contents of the HR and HRC groups were significantly increased compared to the HF group. Uridine 5'-diphospho (UDP)-glucuronyl transferase activity of the HR and HRC groups were increased compared to the HF group. Total bile acid contents of the HR and HRC groups were increased compared to the HF group, and that of the HRC group was significantly increased compared to the HF groups. These results suggest that Rosa multiflora supplementation has powerful health benefits due to UDP-glucuronyl transferase activity, bile acid, and lipid metabolism.

본 연구에서는 고지방 고콜레스테롤 식이 흰쥐에서 찔레꽃과 찔레꽃 복합물이 혈청 및 간 조직의 지질대사에 미치는 영향을 관찰하였다. 실험군을 4군으로 나누어 정상 식이군(N군), 고지방 고콜레스테롤 식이군(HF군), 고지방 고콜레스테롤 식이에 찔레꽃을 5% 첨가한 군(HR군), 고지방 고콜레스테롤 식이에 찔레꽃 복합물을 첨가한 군(HRC군)으로 나누었다. 찔레꽃 복합물은 찔레꽃, 뱀딸기풀, 곰보배추, 조릿대로 구성되어 있다. 체중증가량과 식이효율은 HF군이 N군에 비해 유의적으로 증가하였고 HR군과 HRC군이 HF군에 비해 감소하였다. 혈청 중성지질은 HF군이 N군에 비해 유의적으로 증가하였고 HRC군은 유의적으로 크게 감소하였다. 혈청 HDL-cholesterol은 HR군과 HRC군이 HF군에 비해 증가하였다. 혈청 총콜레스테롤과 LDL-cholesterol은 HF군이 N군에 비해 유의적으로 증가하였고, 특히 동맥경화지수에서 HRC군은 HF군에 비해 유의적으로 감소하였다. 간 중성지질과 총콜레스테롤은 HF군이 N군에 비해 유의적으로 증가하였고 HR군과 HRC군은 HF군에 비해 유의적으로 감소하였다. 대변 중성지질과 총콜레스테롤은 HR군과 HRC군이 HF군에 비해 유의적으로 증가하였다. UDP-glucuronyl transferase 활성은 HR군과 HRC군이 HF군에 비해 증가하였다. Total bile acid는 HR군과 HRC군이 HF군에 비해 증가하였고, 특히 HRC군은 HF군에 비해 유의적으로 증가하였다. 이러한 결과 찔레꽃과 찔레꽃 복합물은 UDP-glucuronyl transferase 활성, total bile acid 및 지질 대사 조절에 효과적으로 활용될 수 있다고 사료된다.

Keywords

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