Textile Science and Engineering (한국섬유공학회지)

The Korean Fiber Society (한국섬유공학회)
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Biodegradable Chitosan/PLGA/Polysorbate80 Nanofibrous Mat Fabrication and Application to Tissue-adhesion Barriers

Chitosan/PLGA/Polysorbate80 생분해성 나노섬유의 제조 및 조직유착방지제로의 응용

  • Kim, Daeyeon (Department of Polymer Science and Engineering, Kumoh National Institute of Technology) ;
  • Bang, Sumi (Department of Polymer Science and Engineering, Kumoh National Institute of Technology) ;
  • Kim, Cheol Joo (Department of Polymer Science and Engineering, Kumoh National Institute of Technology) ;
  • Kim, Won Il (Department of Polymer Science and Engineering, Kumoh National Institute of Technology) ;
  • Kwon, Oh Hyeong (Department of Polymer Science and Engineering, Kumoh National Institute of Technology)
  • 김대연 (금오공과대학교 고분자공학과) ;
  • 방수미 (금오공과대학교 고분자공학과) ;
  • 김철주 (금오공과대학교 고분자공학과) ;
  • 김원일 (금오공과대학교 고분자공학과) ;
  • 권오형 (금오공과대학교 고분자공학과)
  • Received : 2015.03.07
  • Accepted : 2015.04.13
  • Published : 2015.04.30
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Abstract

In the field of surgery, several instances of adhesions in the abdomen, bowel, uterus, and pelvis are observed. Severe post-operative adhesions cause pain in the pelvis and bowel, infertility, and intestinal obstruction. Despite much interest in preventing postoperative adhesion, these symptoms appear persistently. In this study, various composition of chitosan and PLGA blend nanofibrous sheets containing a small quantity of nonionic surfactant, polysorbate80 were fabricated by electrospining technique for application to anti-adhesion barrier. The average diameter of fabricated nanofibers as determined by SEM ranged between 100 to 130 nm. Surface hydrophilicity and biodegradability of nanofibrous mats increased with increasing chitosan content. However, cell attachment and proliferation on nanofibrous surfaces were decreased with increasing chitosan content, probably due to enhanced hydrophilicity. In vivo animal test confirmed that the Chitosan/PLGA(5:5)/Polysorbate80 nanofibrous sheet was sufficiently effective, than the PLGA nanofibrous sheet, in preventing undesired tissue adhesion.

Keywords

References

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