Nutrition Research and Practice

  • 제9권3호
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  • Pages.227-234
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  • 2015
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice

  • Han, Hye Jin (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Jung, Un Ju (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Kim, Hye-Jin (Food R&D, CJ Cheiljedang Corp.) ;
  • Moon, Byoung Seok (Food R&D, CJ Cheiljedang Corp.) ;
  • Cho, Su-Jung (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Park, Yong Bok (School of Life Science & Biotechnology, Kyungpook National University) ;
  • Lee, Dong Gun (School of Life Science & Biotechnology, Kyungpook National University) ;
  • Choi, Myung-Sook (Department of Food Science and Nutrition, Kyungpook National University)
  • 투고 : 2014.09.18
  • 심사 : 2015.02.05
  • 발행 : 2015.06.01
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초록

BACKGROUND/OBJECTIVES: We investigated the effects of a combination of grape pomace (Vitis labrusca, Campbell Early) and Omija fruit (Schizandra chinensis, Baillon) ethanol extracts on lipid metabolism and antioxidant defense system in diet-induced obese mice. MATERIALS/METHODS: Forty male C57BL/6J mice were divided into four groups and fed high-fat diet (control group, CON) or high-fat diet added 0.5% grape pomace extract (GPE), 0.05% Omija fruit extract (OFE) or 0.5% GPE plus 0.05% OFE (GPE+OFE) for 12 weeks. RESULTS: In contrast to the GPE- or OFE-supplemented groups, the GPE+OFE group showed significantly lower body weight and white adipose tissue weights than the CON group. Moreover, GPE+OFE supplementation significantly decreased plasma total cholesterol and increased the plasma HDL-cholesterol/total-cholesterol ratio (HTR) compared to the control diet. The hepatic triglyceride level was significantly lower in the GPE+OFE and GPE groups by increasing ${\beta}$-oxidation and decreasing lipogenic enzyme compared to the CON group. Furthermore, GPE+OFE supplementation significantly increased antioxidant enzyme activities with a simultaneous decrease in liver $H_2O_2$ content compared to the control diet. CONCLUSIONS: Together our results suggest that supplementation with the GPE+OFE mixture may be more effective in improving adiposity, lipid metabolism and oxidative stress in high-fat diet-fed mice than those with GPE and OFE alone.

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