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Acute Epstein-Barr Virus Hepatitis in a 32 Month Old Female Manifesting as Henoch-Sch$\ddot{o}$nlein Purpura

  • Kim, Hee Jin (Department of Pediatrics, CHA Bundang Medical Center, CHA University) ;
  • Jung, Su Jin (Department of Pediatrics, CHA Bundang Medical Center, CHA University) ;
  • Lee, Jun Ho (Department of Pediatrics, CHA Bundang Medical Center, CHA University)
  • Received : 2015.03.16
  • Accepted : 2015.04.25
  • Published : 2015.04.30

Abstract

Henoch-Sch$\ddot{o}$nlein purpura can result from exposure to an antigen after infection with several types of organisms. However, Henoch-Sch$\ddot{o}$nlein purpura caused by a primary Epstein-Barr virus infection has been rarely reported. Here, we report the case of a 32-month-old female patient who presented with Henoch-Sch$\ddot{o}$nlein purpura. Based on abnormal liver function test results and positive results for Epstein-Barr virus infection markers, a diagnosis of Epstein-Barr virus hepatitis manifesting as Henoch-Sch$\ddot{o}$nlein purpura was made. Treatment with methyl-prednisolone and hydration improved the symptoms, and a switch to oral steroids was effective in completely alleviating the purpura. No recurrence was noted and no liver function abnormalities were detected during the follow up period.

Keywords

References

  1. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000;343:481-92. https://doi.org/10.1056/NEJM200008173430707
  2. Guissa VR, Aragao PA, Marques HH, Jacob CM, Silva CA. Chronic active Epstein-Barr virus infection mimicking Henoch-Schonlein purpura. Acta Reumatol Port 2010;35:513-7.
  3. Shaukat A. Epstein-Barr virus induced hepatitis: An important cause of cholestasis. Hepatol Res 2005;33:24-6. https://doi.org/10.1016/j.hepres.2005.06.005
  4. Kimura H. Severe hepatitis caused by Epstein-Barr virus without infection of hepatocytes. Hum Pathol 2001;32:757-62. https://doi.org/10.1053/hupa.2001.25597
  5. Feranchak AP, Tyson RW, Narkewicz MR, Karrer FM, Sokol RJ. Fulminant Epstein-Barr viral hepatitis: orthotopic liver transplantation and review of the literature. Liver Transpl Surg 1998;4:469-76. https://doi.org/10.1002/lt.500040612
  6. Michelow P, Wright C, Pantanowitz L. A review of the cytomorphology of Epstein-Barr virus-associated malignancies. Acta Cytol 2012;56:1-14. https://doi.org/10.1159/000334235
  7. Kimura H, Nagasaka T, Hoshino Y, Hayashi N, Tanaka N, Xu JL, et al. Severe hepatitis caused by Epstein-Barr virus without infection of hepatocytes. Hum Pathol 2001;23:257-62.
  8. Cheng CC, Chang LY, Shao PL, Lee PI, Chen JM, Lu CY, et al. Clinical manifestations and quantitative analysis of virus load in Taiwanese children with Epstein-Barr virus-associated infectious mononucleosis. J Microbiol Immunol Infect 2007;40:216-21.
  9. McCarthy JT, Hoagland RJ. Cutaneous manifestations of infectious mononucleosis. JAMA 1964;187:153-4.
  10. Mendoza N, Diamantis M, Arora A, Bartlett B, Gewirtzman A, Tremaine AM, et al. Mucocutaneous manifestations of Epstein-Barr virus infection. Am J Clin Dermatol 2008;9:295-305. https://doi.org/10.2165/00128071-200809050-00003
  11. Catalina MD, Sullivan JL, Bak KR, Luzuriaga K. Differential evolution and stability of epitope-specific CD8+ T cell responses in EBV infection. J Immunol 2001;167:4450-7. https://doi.org/10.4049/jimmunol.167.8.4450
  12. Ozen S, Ruperto N, Dillon MJ, Bagga A, Barron K, Davin JC, et al. EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides. Ann Rheum Dis 2006;65:936-41.
  13. Chan KH, Tang WY, Lo KK. Bullous lesions in Henoch-Schonlein purpura. Pediatr Dermatol 2007;24:325-6. https://doi.org/10.1111/j.1525-1470.2007.00416.x
  14. David C. Kimberly M. Hypersensitivity vasculitis in children. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on April 15, 2015)
  15. Toussirot E, Roudier J. Epstein-Barr virus in autoimmune diseases. Best Pract Res Clin Rheumatol 2008;22:883-96. https://doi.org/10.1016/j.berh.2008.09.007
  16. Chen O, Zhu XB, Ren H, Wang YB, Sun R. The imbalance of Th17/Treg in Chinese children with Henoch-Schonlein purpura. Int Immunopharmaco 2013;16:67-71. https://doi.org/10.1016/j.intimp.2013.03.027
  17. Takemura T, Yoshioka K, Murakami K, Akano N, Okada M, Aya N, et al. Cellular localization of inflammatory cytokines in human glomerulonephritis. Virchows Arch 1994;424:459-64.
  18. Kim CJ, Woo YJ, Kook H, Choi YY, Ma JS, Hwang TJ. Henoch-Schonlein purpura nephritis associated with Epstein-Barr virus infection in twins. Pediatr Nephrol 2014;19:247-8.