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A Case-Study of Implementation of Improved Strategies for Prevention of Laboratory-acquired Brucellosis

  • Castrodale, Louisa J. (Alaska Department of Health and Social Services, Division of Public Health) ;
  • Raczniak, Gregory A. (Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Zoonotic and Emerging Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC)) ;
  • Rudolph, Karen M. (Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Zoonotic and Emerging Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC)) ;
  • Chikoyak, Lori (Yukon-Kuskokwim Delta Regional Hospital) ;
  • Cox, Russell S. (Yukon-Kuskokwim Delta Regional Hospital) ;
  • Franklin, Tricia L. (Alaska Department of Health and Social Services, Division of Public Health) ;
  • Traxler, Rita M. (Division of High-consequence Pathogens and Pathology, NCEZID, CDC) ;
  • Guerra, Marta (Division of High-consequence Pathogens and Pathology, NCEZID, CDC)
  • 투고 : 2015.05.19
  • 심사 : 2015.07.21
  • 발행 : 2015.12.30

초록

Background: In 2012, the Alaska Section of Epidemiology investigated personnel potentially exposed to a Brucella suis isolate as it transited through three laboratories. Methods: We summarize the first implementation of the United States Centers for Disease Control and Prevention 2013 revised recommendations for monitoring such exposures: (1) risk classification; (2) antimicrobial postexposure prophylaxis; (3) serologic monitoring; and (4) symptom surveillance. Results: Over 30 people were assessed for exposure and subsequently monitored for development of illness. No cases of laboratory-associated brucellosis occurred. Changes were made to gaps in laboratory biosafety practices that had been identified in the investigation. Conclusion: Achieving full compliance for the precise schedule of serologic monitoring was challenging and resource intensive for the laboratory performing testing. More refined exposure assessments could inform decision making for follow-up to maximize likelihood of detecting persons at risk while not overtaxing resources.

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피인용 문헌

  1. A Review of Laboratory-Acquired Infections in the Asia-Pacific: Understanding Risk and the Need for Improved Biosafety for Veterinary and Zoonotic Diseases vol.3, pp.2, 2015, https://doi.org/10.3390/tropicalmed3020036
  2. Biosafety Concerns Related toBrucellaand Its Potential Use as a Bioweapon vol.23, pp.2, 2015, https://doi.org/10.1177/1535676018771983
  3. An accidental laboratory exposure to Brucella melitensis: the prospective post-exposure management and a detailed investigation into the nature of the exposure vol.67, pp.7, 2018, https://doi.org/10.1099/jmm.0.000772
  4. Laboratory Diagnosis of Human Brucellosis vol.33, pp.1, 2019, https://doi.org/10.1128/cmr.00073-19