Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Adjuvant Metronomic Chemotherapy in a Dog with Nasal Transitional Carcinoma

개의 비강 이행암종에서 메트로노믹항암 요법

  • Park, Hyung-Jin (College of the Veterinary Medicine, Chungnam National University) ;
  • Kim, Ja-Won (College of the Veterinary Medicine, Chungnam National University) ;
  • Jeong, Seong-Mok (College of the Veterinary Medicine, Chungnam National University) ;
  • Choi, Ho-Jung (College of the Veterinary Medicine, Chungnam National University) ;
  • Son, Hwa-Young (College of the Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (College of the Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung-Won (College of the Veterinary Medicine, Chungnam National University)
  • Accepted : 2015.04.10
  • Published : 2015.04.30
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Abstract

A four-year-old spayed female Maltese dog weighing 3 kg was referred with reverse sneezing and fourmonth history of unilateral nasal discharge. She was diagnosed as nasal transitional carcinoma which in bilateral nasal cavity and extending into the frontal sinus by biopsy with rhinoscopy. Metronomic chemotherapy with cyclophosphamide ($12.5mg/m^2$) and toceranib phosphate (2.5 mg/kg) was initiated following after surgical treatment of nasal mass debulking. Clinical response was good and had no side effects during the chemotherapy period (11 months after diagnosis). This is a case report describing adjuvant metronomic chemotherapy in nasal transitional carcinoma in Korea.

4살령의 중성화 암컷 말티즈 견이 4개월에 걸친 편측성 코 분비물 및 코막힘을 주증으로 본원에 내원하였다. 환자는 비강 이행암종이 전두동까지 파급되어 있는 것이 비강 내시경을 통해 확인되었다. 보조적 항암치료로 사이클로포스파마이드($12.5mg/m^2$) 와 티로신 키나아제 억제제인 토세라닙(2.5 mg/kg)을 수술적 부피 감량술 이후에 적용 하였다. 치료반응은 양호 하였으며, 진단 후 11개월 동안 항암치료에 대한 부작용 없이 잘 유지 되었다. 본 증례는 국내에서 비강 이행암종에서 보조적 항암치료를 실시한 최초 보고이다.

Keywords

References

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