References
- Alam, J., Stewart, D., Touchard, C., Boinapally, S., Choi, A.M., and Cook, J.L. (1999). Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J. Biol.Chem. 274, 26071-26078. https://doi.org/10.1074/jbc.274.37.26071
- Bae, J., Lee, D., Kim, Y.K., Gil, M., Lee, J.Y., and Lee, K.J. (2013). Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. Mol. Cells 35, 151-157. https://doi.org/10.1007/s10059-013-2298-5
- Bauer, M., and Bauer, I. (2002). Heme oxygenase-1: Redox regulation and role in the hepatic response to oxidative stress. Antioxid. Redox Signal. 4, 749-758. https://doi.org/10.1089/152308602760598891
- Becker, J.C., Fukui, H., Imai, Y., Sekikawa, A., Kimura, T., Yamagishi, H., Yoshitake, N., Pohle, T., Domschke, W., and Fujimori, T. (2007). Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer. Scand. J. Gastroenterol. 42, 852-858. https://doi.org/10.1080/00365520701192383
- Bezerra, D.P., Pessoa, C., de Moraes, M.O., Saker-Neto, N., Silveira, E.R., and Costa-Lotufo, L.V. (2012). Overview of the therapeutic potential of piplartine (piperlongumine). Eur. J. Pharm. Sci. 48, 453-463.
- Caballero, F., Meiss, R., Gimenez, A., Batlle, A., and Vazquez, E. (2004). Immunohistochemical analysis of heme oxygenase-1 in preneoplastic and neoplastic lesions during chemical hepatocarcinogenesis. Int. J. Exp. Pathol. 85, 213-221. https://doi.org/10.1111/j.0959-9673.2004.00391.x
- Cornblatt, B.S., Ye, L.X., Dinkova-Kostova, A.T., Erb, M., Fahey, J.W., Singh, N.K., Chen, M.S.A., Stierer, T., Garrett-Mayer, E., Argani, P., et al. (2007). Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis 28, 1485-1490. https://doi.org/10.1093/carcin/bgm049
- Dent, G., Rabe, K.F., and Magnussen, H. (1997). Augmentation of human neutrophil and alveolar macrophage LTB4 production by N-acetylcysteine: role of hydrogen peroxide. Br. J. Pharmacol. 122, 758-764. https://doi.org/10.1038/sj.bjp.0701428
- Ewing, P., Wilke, A., Eissner, G., Holler, E., Andreesen, R., and Gerbitz, A. (2005). Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis. Endothelium 12, 113-119. https://doi.org/10.1080/10623320500189814
- Hill, M., Pereira, V., Chauveau, C., Zagani, R., Remy, S., Tesson, L., Mazal, D., Ubillos, L., Brion, R., Ashgar, K., et al. (2005). Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J. 19, 1957-1968. https://doi.org/10.1096/fj.05-3875com
- Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997). An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236, 313-322. https://doi.org/10.1006/bbrc.1997.6943
- Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J.D., and Yamamoto, M. (1999). Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13, 76-86. https://doi.org/10.1101/gad.13.1.76
- Kensler, T.W., Wakabayashi, N., and Biswal, S. (2007). Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47, 89-116. https://doi.org/10.1146/annurev.pharmtox.46.120604.141046
- Keum, Y.S., Han, Y.H., Liew, C., Kim, J.H., Xu, C.J., Yuan, X.L., Shakarjian, M.P., Chong, S.H., and Kong, A.N. (2006). Induction of heme oxygenase-1 (HO-1) and NAD[P]H: Quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tertbutylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes. Pharm. Res. 23, 2586-2594. https://doi.org/10.1007/s11095-006-9094-2
- Kim, H.J., So, H.S., Lee, J.H., Lee, J.H., Park, C., Park, S.Y., Kim, Y.H., Youn, M.J., Kim, S.J., Chung, S.Y., et al. (2006). Heme oxygenase-1 attenuates the cisplatin-induced apoptosis of auditory cells via down-regulation of reactive oxygen species generation. Free Radic. Biol. Med. 40, 1810-1819. https://doi.org/10.1016/j.freeradbiomed.2006.01.018
- Kim, S.H., Lee, I.C., Baek, H.S., Shin, I.S., Moon, C., Bae, C.S., Kim, S.H., Kim, J.C., and Kim, H.C. (2014). Mechanism for the protective effect of diallyl disulfide against cyclophosphamide acute urotoxicity in rats. Food Chem. Toxicol. 64, 110-118. https://doi.org/10.1016/j.fct.2013.11.023
- Kobayashi, A., Kang, M.I., Watai, Y., Tong, K.I., Shibata, T., Uchida, K., and Yamamoto, M. (2006). Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol. Cell. Biol. 26, 221-229. https://doi.org/10.1128/MCB.26.1.221-229.2006
- Kobayashi, M., Li, L., Iwamoto, N., Nakajima-Takagi, Y., Kaneko, H., Nakayama, Y., Eguchi, M., Wada, Y., Kumagai, Y., and Yamamoto, M. (2009). The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds. Mol. Cell. Biol. 29, 493-502. https://doi.org/10.1128/MCB.01080-08
- Lee, W.Y., Chen, Y.C., Shih, C.M., Lin, C.M., Cheng, C.H., Chen, K.C., and Lin, C.W. (2014). The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide. Toxicol. Appl. Pharmacol. 274, 55-62. https://doi.org/10.1016/j.taap.2013.10.027
- Lin, H.Y., Shen, S.C., and Chen, Y.C. (2005). Anti-inflammatory effect of heme oxygenase 1: Glycosylation and nitric oxide inhibition in macrophages. J. Cell Physiol. 202, 579-590. https://doi.org/10.1002/jcp.20160
- Lin, H.Y., Shen, S.C., Lin, C.W., Yang, L.Y., and Chen, Y.C. (2007). Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. Biochim. Biophys. Acta 1773, 1073-1086. https://doi.org/10.1016/j.bbamcr.2007.04.008
- Lin, C.W., Shen, S.C., Hou, W.C., Yang, L.Y., and Chen, Y.C. (2008). Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9. Mol. Cancer Ther. 7, 1195-1206. https://doi.org/10.1158/1535-7163.MCT-07-2199
- Liu, J.M., Pan, F., Li, L., Liu, Q.R., Chen, Y., Xiong, X.X., Cheng, K.J., Bin Yu. S., Shi, Z., Yu, A.C.H., et al. (2013). Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem. Biophys. Res. Commun. 437, 87-93. https://doi.org/10.1016/j.bbrc.2013.06.042
- Raj, L., Ide, T., Gurkar, A.U., Foley, M., Schenone, M., Li, X., Tolliday, N.J., Golub, T.R., Carr, S.A., Shamji, A.F., et al. (2011). Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475, 231-234. https://doi.org/10.1038/nature10167
- Rao, V.R., Muthenna, P., Shankaraiah, G., Akileshwari, C., Babu, K.H., Suresh, G., Babu, K.S., Chandra Kumar, R.S., Prasad, K.R., Yadav, P.A., et al. (2012). Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs). Eur. J. Med. Chem. 57, 344-361. https://doi.org/10.1016/j.ejmech.2012.09.014
- Russo, M., Spagnuolo, C., Tedesco, I., and Russo, G.L. (2010). Phytochemicals in Cancer Prevention and Therapy: Truth or Dare? Toxins 2, 517-551. https://doi.org/10.3390/toxins2040517
- Son, D.J., Kim, S.Y., Han, S.S., Kim, C.W., Kumar, S., Park, B.S., Lee, S.E., Yun, Y.P., Jo, H., and Park, Y.H. (2012). Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem. Biophys. Res. Commun. 427, 349-354. https://doi.org/10.1016/j.bbrc.2012.09.061
- Tsuji, M.H., Yanagawa, T., Iwasa, S., Tabuchi, K., Onizawa, K., Bannai, S., Toyooka, H., and Yoshida, H. (1999). Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis. Cancer lett. 138, 53-59. https://doi.org/10.1016/S0304-3835(98)00372-3
- Yamamoto, T., Suzuki, T., Kobayashi, A., Wakabayashi, J., Maher, J., Motohashi, H., and Yamamoto, M. (2008). Physiological significance of reactive cysteine residues of keap1 in determining Nrf2 activity. Mol. Cell. Biol. 28, 2758-2770. https://doi.org/10.1128/MCB.01704-07
- Yang, Y.C., Lee, S.G., Lee, H.K., Kim, M.K., Lee, S.H., and Lee, H.S. (2002). A piperidine amide extracted from Piper longum L. fruit shows activity against Aedes aegypti mosquito larvae. J. Agric. Food Chem. 50, 3765-3767. https://doi.org/10.1021/jf011708f
- Zhang, D.D., Lo, S.C., Cross, J.V., Templeton, D.J., and Hannink, M. (2004). Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell. Biol. 24, 10941-10953. https://doi.org/10.1128/MCB.24.24.10941-10953.2004
- Zou, C., Zhang, H., Li, Q., Xiao, H., Yu, L., Ke, S., Zhou, L., Liu, W., Wang, W., Huang, H., et al. (2011). Heme oxygenase-1: a molecular brake on hepatocellular carcinoma cell migration. Carcinogenesis 32, 1840-1848. https://doi.org/10.1093/carcin/bgr225
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