The Korean journal of internal medicine

  • 제30권5호
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  • Pages.719-726
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  • 2015
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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DOI QR코드

DOI QR Code

Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population

  • Do, Sook Kyung (Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Yoo, Seung Soo (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Choi, Yi Young (Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Choi, Jin Eun (Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Jeon, Hyo-Sung (Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Lee, Won Kee (Department of Preventive Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Shin Yup (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Jaehee (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Cha, Seung Ick (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Kim, Chang Ho (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Park, Jae Yong (Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine)
  • 투고 : 2014.04.18
  • 심사 : 2014.12.02
  • 발행 : 2015.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population. Methods: Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction. Results: Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated with telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes ($p=1.7{\times}10^{-5}$). Conclusions: We have identified polymorphisms associated with telomere length in a Korean population.

키워드

과제정보

연구 과제 주관 기관 : Ministry of Health and Welfare

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