Radiation Oncology Journal

  • 제33권1호
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  • Pages.36-41
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  • 2015
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
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Post-treatment intracranial hemorrhage of brain metastases from hepatocellular carcinoma

  • Kim, Kyung Su (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Kim, Kyubo (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Chie, Eui Kyu (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Kim, Yoon Jun (Departrment of Internal Medicine, Seoul National University College of Medicine) ;
  • Yoon, Jung Hwan (Departrment of Internal Medicine, Seoul National University College of Medicine) ;
  • Lee, Hyo-Suk (Departrment of Internal Medicine, Seoul National University College of Medicine) ;
  • Ha, Sung W. (Department of Radiation Oncology, Seoul National University College of Medicine)
  • 투고 : 2015.02.05
  • 심사 : 2015.03.13
  • 발행 : 2015.03.31
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초록

Purpose: To evaluate the incidence and risk factors of post-treatment intracranial hemorrhage of brain metastases from hepatocellular carcinoma (HCC). Materials and Methods: Medical records of 81 patients who have been diagnosed of brain metastases from HCC and underwent surgery, radiosurgery and/or whole brain radiotherapy (WBRT) between January 2000 and December 2013 were retrospectively reviewed. Results: Intracranial hemorrhage was present in 64 patients (79%) at the time of diagnosis. Median value of alpha-fetoprotein (AFP) level was 1,700 ng/mL. The Eastern Cooperative Oncology Group (ECOG) performance status for 20 patients was greater than 2. Fifty-seven patients underwent WBRT and the others were treated with surgery and/or radiosurgery without WBRT. During follow-up, 12 events of intracranial hemorrhage after treatment were identified. Three-month post-treatment hemorrhage rate was 16.1%. Multivariate analyses revealed that ECOG performance status, AFP, and WBRT were associated with post-treatment hemorrhage (p = 0.013, 0.013, and 0.003, respectively). Kaplan-Meier analysis showed that 3-month post-treatment hemorrhage rate of new lesion was higher in patients treated without WBRT, although statistical significance was not reached. (18.6% vs. 4.6%; p = 0.104). Ten of 12 patients with post-treatment hemorrhage died with neurologic cause. Conclusion: WBRT should be considered to prevent post-treatment hemorrhage in the treatment of brain metastases from HCC.

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참고문헌

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피인용 문헌

  1. Clinical outcomes of brain metastases from hepatocellular carcinoma: a multicenter retrospective study and a literature review vol.23, pp.6, 2015, https://doi.org/10.1007/s10147-018-1312-5
  2. Intracranial Bleeding during Treatment with Sorafenib for Hepatocellular Carcinoma vol.8, pp.6, 2015, https://doi.org/10.1159/000496546