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수중에서 금속 촉매의 니트릴 수화 반응에 의한 환경친화적 아미드 합성

Environmentally Friendly Synthesis of Amide by Metal-catalyzed Nitrile Hydration in Aqueous Medium

  • 투고 : 2015.03.17
  • 발행 : 2015.04.10

초록

친환경적 조건에서의 니트릴의 수화 반응은 아미드를 생산하기 위한 가장 경제적이고 매력적인 방법이다. 고체 금속 산화물과 지지체를 이용한 전이 금속 촉매 시스템은 이러한 니트릴 수화 반응을 보다 향상시키기 위한 의미 있는 연구로써 수행되어져 왔다. 이들 촉매들의 중요한 특징은 방향족, 지방족, 이종 원자형, 지방족 고리형 등의 니트릴들을 포함하는 넓은 범위의 다양한 기질들에 적용된다는 것이다. 또한 이들은 높은 촉매적 활성을 유지하면서 여러 번의 재사용성이 가능하고 반응 후 그 혼합물로부터 분리가 용이하다는 장점들을 갖는다. 이 리뷰를 통하여 니트릴 수화반응을 통한 아미드 합성에 적용되는 금속 산화물과 지지체를 가진 금속 촉매들에 대해 알아본다.

Hydration of nitriles in the environmentally benign neutral conditions is the most economical and attractive way to produce amides. Substantial research works have been carried out to apply the solid metal oxides and transition metal supported catalytic systems to promote the hydration of nitriles. The most significant feature of these catalysts is the applicability to a wide range of substrates including aromatic, alicyclic, hetero-atomic, and aliphatic nitriles. These catalysts are also characterized by the easy isolation from the reaction mixture and the reusability while maintaining the high catalytic activity. This review accounts over the detailed survey of the metal oxide and solid supported metal catalysts for preparing amides from the hydration of nitriles.

키워드

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피인용 문헌

  1. -alkylation of amides with alcohols vol.17, pp.8, 2019, https://doi.org/10.1039/C8OB03091J
  2. Selective Hydration of Nitriles to Corresponding Amides in Air with Rh(I)-N-Heterocyclic Complex Catalysts vol.10, pp.1, 2015, https://doi.org/10.3390/catal10010125
  3. Catalytic hydration of cyanamides with phosphinous acid-based ruthenium(II) and osmium(II) complexes: scope and mechanistic insights vol.10, pp.12, 2020, https://doi.org/10.1039/d0cy00523a
  4. Access to α‐ and β‐Hydroxyamides and Ureas Through Metal‐Catalyzed C≡N Bond Hydration and Transfer Hydration Reactions vol.2021, pp.32, 2015, https://doi.org/10.1002/ejic.202100413