Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Clinical Evaluation between Overtraining Syndrome and Exercise-related Immunity

과훈련증후군과 면역반응의 임상적 분석

  • Choi, Seung-Jun (Department of Sports and Health Science, Kyung-Sung University) ;
  • Park, Song-young (Whitaker Cardiovascular Institute, Boston University School of Medicine) ;
  • Kwak, Yi-Sub (Department of Physical Education, Dong-Eui University)
  • 최승준 (경성대학교 스포츠건강학부) ;
  • 박송영 (보스턴 의과대학교 순환기내과) ;
  • 곽이섭 (동의대학교 체육학과)
  • Received : 2015.10.19
  • Accepted : 2015.11.24
  • Published : 2015.11.30
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Abstract

The present study was performed to analyze and review the physical and immune responses to overtraining syndrome in humans. Overreaching refers to the initial phage of overtraining syndrome and has been known as a physical fatigue which is mainly from metabolic imbalance. It has been known that overtraining also results in a loss of adaptability which may lead to an attenuation of exercise performance, sleeping disorder, central fatigue, neurohormonal changes, difficulty recovery to physical stress, and immunological changes. Additionally, overtraining syndrome is characterized by persistent fatigue, poor performance in sport due to the prolonged and strenuous physical training. Also, previous studies reported that endurance athletes experienced a high incidence of URTI during intense training and the post training. And also, high-performance athletes reported that suppression of cell mediated and anti-body mediated immune function. NK cell numbers were also reduced in the period of overtraining syndrome. Major components of prevention and treatment for the overtraining syndrome are screening, education, and detraining. Furthermore, the combination of these prevention and treatment strategies will be much helpful. Therefore, the current review will be helpful for athletes and individuals who are at the risk of overtraining syndrome.

운동에 종사하는 엘리트 운동선수나 동호인들은 지속적인 같은 동작의 반복, 잦은 경쟁스트레스의 경험, 그리고 신체적인 컨디션이 좋지 않은 상황에서의 과도한 훈련의 요구 때문에 근육, 건, 인대, 염좌 및 골절과 같은 부상을 비롯한 근골격계 질환을 야기한다. 그리고 과도한 오버리칭, 경쟁불안으로 인한 스트레스, 및 피로회복의 부족 등으로 운동기술의 정체를 비롯한 운동수행력의 감소는 물론 심리적인 스트레스와 면역반응의 감소를 경험하게 된다. 따라서 본 연구에서는 과훈련증후군의 원인과 증상 및 치료와 처치에 대해 분석하고 이러한 증후군과 면역반응과 연관성을 비교 및 분석하여 운동 동호인을 비롯한 운동 선수들에게 나타날 수 있는 면역력의 감소를 줄여, 운동수행력의 증진은 물론 건강유지와 면역력 회복을 도모하고자 한다. 본 연구의 목적을 달성하기 위해 본론에서는 과훈련 증후군에 대한 전반적인 내용을 실험연구를 비롯한 관련 연구논문을 중심으로 분석하였고, 아울러 과훈련 증후군과 면역반응 및 알레르기 면역반응과의 연관성에 대해 면밀한 분석을 실시하였다. 본 연구 결과를 토대로 많은 스포츠 현장에서 과훈련증후군에 관한 실험적인 연구와 면역반응 및 알레르기반응과의 연관성 분석을 토대로 한 실험적 연구가 진행되어야 할 것으로 여겨지며, 본 연구가 많은 운동선수들과 동호인들의 건강관리는 물론, 면역력의 증가를 도모하는 데에 도움을 줄 것으로 여겨진다.

Keywords

References

  1. Ackel-D’Elia, C., Vancini, R. L., Castelo, A., Nouailhetas, V. L. and Silva, A. C. 2015. Absence of the predisposing factors and signs and symptoms usually associated with overreaching and overtraining in physical fitness centers. Clinics 65, 1161-1166.
  2. Angeli, A., Minetto, M., Dovio, A. and Paccotti, P. 2004. The overtraining syndrome in athletes: a stress-related disorder. J. Endocrinol. invest. 6, 603-612.
  3. Apostolopoulos, V., Borkoles, E., Polman, R. and Stojanovska, L. 2014. Physical and immunological aspects of exercise in chronic diseases. Immunotherapy 6, 1145-1157. https://doi.org/10.2217/imt.14.76
  4. Blundell, J. E., Gibbons. C., Caudwell, P., Finlayson, G. and Hopkins, M. 2015. Appetite control and energy balance: impact of exercise. Obes. Rev. 1, 67-76.
  5. Brich, K. and George, K. 1999. Overtraining the female athlete. J. Bodyw. Mov. Ther. 3, 24-29. https://doi.org/10.1016/S1360-8592(99)80039-4
  6. Brooks, K. and Carter, J. 2013. Overtraining, exercise, and adrenal insufficiency. J. Nov. Physiother. 3, 1-10.
  7. Carfangno, D. G. and Hendri, J. C. 3rd. 2014. Overtraining syndrome in the athlete: current clinical practice. Curr. Sports Med. Rep. 13, 45-51. https://doi.org/10.1249/JSR.0000000000000027
  8. Eichner, E. R. 1995. Overtraining: consequences and prevention. J. Sports Sci. 13, 41-48. https://doi.org/10.1080/02640419508732276
  9. Gremion, G. and Kuntzer, T. 2014. Fatigue and reduction in motor performance in sportspeople or overtraining syndrome. Rev. Med. Suisse. 10, 962-965.
  10. Guezennec, C. Y. 2004 Overtraining syndrome. Bull. Acad. Natl. Med. 188, 923-930.
  11. Hackney, A. C. and Koltun, K. J. 2012. The immune system and overtraining in athletes: clinical implications. Acta. Clin. Croat. 51, 633-641.
  12. Hackney, A. C. 2013. Clinical management of immune-suppression in athletes associated with exercise training: sports medicine considerations. Acta. Med. Iran. 51, 751-756.
  13. Halson, S. L. and Jeukendrup, A. E. 2004. Does overtraining exist? An analysis of overreaching and overtraining research. Sports Med. 34, 967-981. https://doi.org/10.2165/00007256-200434140-00003
  14. Hawley, C. J. and Schoene, P. B. 2003. Overtraining syndrome: a guide to diagnosis, treatment, and prevention. Phys. Sportsmed. 31, 25-31.
  15. He, C. S., Bishop, N. C., Handzik, M. K., Muhamad, A. S. and Gleeson, M. 2014. Sex differences in upper respiratory symptoms prevalence and oral-respiraory mucosal immunity in endurance athletes. Exerc. Immunol. Rev. 20, 8-22.
  16. Jayasinghe, H., Kopsaftis, Z. and Carson, K. 2015. Asthma bronchiale and exercise-induced bronchoconstriction. Respiration 89, 505-512. https://doi.org/10.1159/000433559
  17. Jin, C. H., Paik, I. Y., Kwak, Y. S., Jee, Y. S. and Kim, J. Y. 2015. Exhaustive submaximal endurance and resistance exercise induce temporary immunosuppression via physical and oxidative stress. J. Exerc. Rehabil. 11, 198-203 https://doi.org/10.12965/jer.150221
  18. Kim, C. W., Figueroa, A., Park, C. H., Kwak, Y. S., Kim, K. B., Seo, D. Y. and Lee, H. R. 2013. Combined effects of food and exercise on anaphylaxis. Nutr. Res. Pract. 7, 347-351. https://doi.org/10.4162/nrp.2013.7.5.347
  19. Kreher, J. B. and Schwartz, J. B. 2012. Overtraining syndrome: a practical guide. Sports Health. 4, 123-138.
  20. Lakier Smith, L. 2003. Overtraining, excessive exercise, and altered immunity: is this a Thelper-1 versus T helper-2 lymphocyte response? Sports Med. 33, 347-364. https://doi.org/10.2165/00007256-200333050-00002
  21. Laurel, T. M. 2000. Overtraining effects on immunity and performance in athletes. Immunol. Cell Biol. 78, 502-509. https://doi.org/10.1111/j.1440-1711.2000.t01-7-.x
  22. Le Meur, Y., Hausswirth, C., Natta, F., Couturier, A., Bignet, F. and Vidal, P. P. 2013. A multidisciplinary approach to overreaching detection in endurance trained athletes. J. Appl. Physiol. 114, 411-420. https://doi.org/10.1152/japplphysiol.01254.2012
  23. Lee, H. K., Hwang, I. H., Kim, S. Y. and Pyo, S. Y. 2014. The effect of exercise on prevention of the common cold: a meta-analysis of randomized controlled trial studies. Kor. J. Fam. Med. 35, 119-126. https://doi.org/10.4082/kjfm.2014.35.3.119
  24. Li, C. Y., Hsu, G. S., Suzuki, K., Ko, M. H. and Fang, S. H. 2015. Salivary immune Factors, Cortisol and Testosterone Responses in Atheletes of a Competitive 5,000m Race. Chin. J. Physiol. 58, 263-269. https://doi.org/10.4077/CJP.2015.BAE367
  25. Mackinnon, L. T. and Hooper, S. 1994. Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining. Int. J. Sports Med. 3, 179-183.
  26. Margonis, K., Fatouros, I. G., Jamurtas, M. Z., Nikolaidis, M. G., Douroudos, I., Chatzinikolaou, A., Mitrakou, A., Mastorakos, G., Papassotiriou, I., Taxildaris, K. and Kouretas, D. 2007. Oxidative stress biomarkers responses to physical overtraining: implications for diagonosis. Free Radic. Biol. Med. 43, 901-910. https://doi.org/10.1016/j.freeradbiomed.2007.05.022
  27. Matsuo, H., Yokooji, T. and Taogoshi, T. 2015. Common food allergens and their IgE-binding epitopes. Allergol. Int. 64, 332-343. https://doi.org/10.1016/j.alit.2015.06.009
  28. Meeusen, R., Duclos, M., Foster, C., Gleeson, M., Nieman, D., Raqlin, J., Rietjens, G., Steinacker, J. and Urhausen, A. 2013. Prevention, diagnosis, and treatment of the overtaining syndrom. Med. Sci. Sports Exers. 45, 186-205. https://doi.org/10.1249/MSS.0b013e318279a10a
  29. Michael, G. 2002. Biochemical and immunological markers of over-training. J. Sports Sci. Med. 1, 31-41.
  30. Montgomery, S. L. 2015. Cholinergic urticaria and exercise-induced anaphylaxis. Curr. Sports Med. Rep. 14, 61-63. https://doi.org/10.1249/JSR.0000000000000111
  31. Morton, R. W., McGlory, C. and Phillips, S. M. 2015. Nutritional interventions to augment resistance training- induced skeletal muscle hypertrophy. Front. Physiol. 6, 245.
  32. Nicolas, M., Banizette, M. and Millet, G. Y. 2011. Stress and recovery states after a 24 h ultra-marathon race: A onemonth follow-up study. Psychol. Sport Exerc. 12, 368-374. https://doi.org/10.1016/j.psychsport.2011.03.005
  33. Nieman, D. C. 2000. Is infection risk linked to exercise workload?. Med. Sci. Sports Exerc. 32, 406-411. https://doi.org/10.1097/00005768-200007001-00005
  34. Peijie, C., Hongwu, L., Fengpeng, X., Jie, R. and Jie, Z. 2003. Heavy load exercise induced dysfunction of immunity and neuroendocrine responses in rats. Life Sci. 72, 2252-2262.
  35. Purvis, D., Gonsalves, S. and Deuster, P. A. 2010. Physiological and psychological fatigue in extreme conditions: overtraining and elite athletes. PM R. 2, 412-450.
  36. Rowbottom, D. G., Keast, D., Goodman, C. and Morton, A. R. 1995. The hematological, biochemical and immunological profile of atheletes suffering from the overtraining syndrome. Eur. J. Appl. Physiol. Occup. Physiol. 70, 502-509. https://doi.org/10.1007/BF00634379
  37. Sharp, N. C. and Koutedakis, Y. 1992. Sport and the overtraining syndrome: immunological aspects. Br. Med. Bull. 48, 518-533.
  38. Shephard, R. J. 2001. Chronic fatigue syndrome: an update. Sports Med. 31, 167-194. https://doi.org/10.2165/00007256-200131030-00003
  39. Silva, D. and Moreira, A. 2015. The role of sports and exercise in allergic disease: drawbacks and benefits. Expert Rev. Clin. Immunol. 11, 993-1003. https://doi.org/10.1586/1744666X.2015.1058158
  40. Smith, L. L. 2000. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress? Med. Sci. Sports Exerc. 32, 317-331. https://doi.org/10.1097/00005768-200002000-00011
  41. Tian, Y., He, Z., Zhao, J., Tao, D., Xu, K., Midgley, A. and McNaughton, L. 2015. An 8-year longitudinal study of overreaching in 114 elite female Chinese wreslers. J. Ahtl. Train 50, 217-223. https://doi.org/10.4085/1062-6050-49.3.57
  42. Tipton, K. D. and Phillips, S. M. 2013. Dietary protein for muscle hypertrophy. Nestle Nutr. Inst. Workshop Ser. 76, 73-84. https://doi.org/10.1159/000350259
  43. Vuljanko, I. M. and Plavec, D. 2014. Exercise-induced asthma in athletes-a review. Lijec. Vjesn. 136, 339-345.
  44. Winsley, R. and Matos, N. 2011. Overtraining and elite young athletes. Med. Sport. Sci. 56, 97-105.
  45. Zoppi, C. C. and Macedo, D. V. 2008. Overreaching-induced oxidative stress, enhanced HSP72 expression, antioxidant and oxidative enzymes downregulation. Scand. J. Med. Sci. Sports 18, 67-76.