Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Two New Scalaranes from a Korean Marine Sponge Spongia sp.

  • Yang, Inho (School of Earth and Environmental Sciences, Seoul National University) ;
  • Nam, Sang-Jip (Department of Chemistry and Nano Science, Global Top5 Program, Ewha Womans University) ;
  • Kang, Heonjoong (School of Earth and Environmental Sciences, Seoul National University)
  • Received : 2015.06.30
  • Accepted : 2015.08.17
  • Published : 2015.12.31
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Abstract

Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of $^1H-^1H$ coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.

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References

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