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Other Processed Products, Monitoring and the Exposed Dose Assessment of Heavy Metal, the Illegal Compounds

기타가공품의 중금속, 부정유해물질 모니터링 및 노출량 평가

  • Jang, Jin-Seob (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Kwon, Mun-Ju (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Kim, Meyong-Hee (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Park, Jin-Soo (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Lim, Soo-Sun (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Kwon, Sung-Hee (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Song, Sung-Min (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Yeo, Eun-Young (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Hong, Seong-Hee (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Kim, Jung-Im (Dept. of Food Analysis, Incheon metropolitan city Research Institute of Public Health and Environment) ;
  • Om, Ae-Son (Dept. of Food and Nutrition, Hanyang University)
  • 장진섭 (인천광역시 보건환경연구원 식품분석과) ;
  • 권문주 (인천광역시 보건환경연구원 식품분석과) ;
  • 김명희 (인천광역시 보건환경연구원 식품분석과) ;
  • 박진수 (인천광역시 보건환경연구원 식품분석과) ;
  • 임수선 (인천광역시 보건환경연구원 식품분석과) ;
  • 권성희 (인천광역시 보건환경연구원 식품분석과) ;
  • 송성민 (인천광역시 보건환경연구원 식품분석과) ;
  • 여은영 (인천광역시 보건환경연구원 식품분석과) ;
  • 홍성희 (인천광역시 보건환경연구원 식품분석과) ;
  • 김정임 (인천광역시 보건환경연구원 식품분석과) ;
  • 엄애선 (한양대학교 식품영양학과)
  • Received : 2014.02.24
  • Accepted : 2014.09.19
  • Published : 2015.03.30

Abstract

This study was performed for both evaluating the safety of other processed products and providing basic information for making the general standard for contaminants in the category of other processed products. We analyzed the contents of three heavy metals, thirty six anti-impotence drugs and their analogues, three anti-obesity drugs and their analogues, twenty eight steroid drugs and their analogues, collecting in Incheon Metropolitan City. Any illegal compound was not detected in those products. However the contents of lead, cadmium and mercury of those products were at the range of 0.001-13.390 mg/kg, 0.03-1.231 mg/kg and 0.001-0.650 mg/kg respectively. Because there are no standards of heavy metals against other processed products, we compared the analytical results with relevant standards of both S. Korea and foreign countries. As a result, two products exceeded the relevant standards of lead, and other two products exceeded the relevant standards of mercury. The relative hazards compared to PTWI of FAO/WHO (Codex), Seafoods-pajeonmix, Perilla seed powder exceeded PTWI standards 0.214. The compulsory standards of each food product are determined by the category of the products. Because there is no standard of heavy metals in the category of other processed products in S. Korea, any food products registered as other processed product by manufacturer are free with those standards. Abusing similar problems on the categorization of food products could cause consumers' health problem. To prevent these problems, detail regulations on the categorization of food products have to be introduced.

본 연구는 인천광역시내 유통되고 있는 기타가공품에 대하여 중금속 (납, 카드뮴, 수은), 부정유해물질 (발기부전치료제와 그 유사물질 36종, 비만치료제 3종, 스테로이드 28종)을 조사하여 안전성을 평가하고, 기타가공품에 대한 기준규격 제정 시 기초자료로서 제공하고자 실시하였다. 그결과 부정유해물질은 검출되지 않았고, 중금속은 납(Pb) 0.001~13.39(mg/kg), 카드뮴(Cd) 0.003~1.231(mg/kg), 수은(Hg)은 0.001~0.650(mg/kg)의 결과를 얻었다. 기타가공품은 중금속에 대한 규격 기준이 없으므로, 중금속의 국내 외 기준을 비교하였을 때 중금속 최고기준을 적용하면 납(Pb)과 수은(Hg)에서 각각 2건씩 4건이 초과되는 것으로 확인되었다. 검사결과를 바탕으로 한 중금속의 위해성 평가는 FAO/WHO (Codex)의 잠정주간섭취허용량(PTWI)과 비교결과, 해물파전믹스, 들깨가루는 Pb의 PTWI의 기준 0.214를 초과하였다. 결론적으로 분말류나 환제품을 유사식품 기준으로 적용하면 부적합으로 판정 될 수 있기 때문에 규격검사를 피할 목적으로 기타가공품으로의 등록을 지향한다. 이를 악용할 경우 검사의 사각지대로 인해 시민의 건강이 위협받을 수 있다. 따라서 품목제조허가 신고시 규격외 일반가공식품에서 기타가공품으로의 등록을 지양하고, 기타가공품의 세부적인 검사규격을 제정하여 관리해야 함을 제언한다.

Keywords

References

  1. 식품의약품안전처: 식품의약품 안전평가원 Analytical methods of illegal compounds in food (2013).
  2. 식품의약품안전청: 식품 중 신종 부정유해물질의 사전예 측적 합성 및 실태조사. Vol 11, (2007).
  3. 식품의약품안전처: 식품공전 (2013).
  4. 식품의약품안전처: 식품공전 시험법 II 7.4-7.5 (2013).
  5. 식품의약품안전처: 2012년도 식품 및 식품첨가물 생산실적 통계집 (2013).
  6. 식품의약품안전청: 부정유해물질 탐색 및 확인연구 결과 보고서 (2006).
  7. 농촌진흥청 국립농업과학원: 농산물 중 중금속 분석법 및 정도관리 지침서 (2011).
  8. 농산물의 중금속 기준 및 현황. http://blog.daum.net/dackkal/3324451.
  9. 중금속 독소, 농약, PTWI 허용치. http://wanabe00.blog.me/50113567587.
  10. Ock kyoung Chun, Yeon chen Kim, Sun hee Han.: A study on the contents of Heavy Metals in the commercial processed foods. J. Food Hyg.Safety, 16(4), 308-314 (2001).
  11. Sung-deuk Lee, Young-ki Lee, Moo-sang Kim, Seok-ki Park, Yeon-sun Kim, Young-zoo Chae.: The Content and Risk Assessment of Heavy Metals in Herbal Pills. J. Food Hyg. Safety, 375-387 (2012).
  12. Choi DM.: Structure elucidation and determination of illegal compounds (anti-impotence drug analogues) in foods. Anal. Sci. Tech., 21, 65-83 (2008).
  13. Reepmeyer JC, d'vignon DA.: Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs. J. Pharmaceut. Biomed., 49, 145-150 (2009). https://doi.org/10.1016/j.jpba.2008.10.007
  14. Mee-hye Kim, Hyun-sook Lee, Joon-goo Lee, Jin-chul Kim, Jae-ho Oh, Young-mi Jang.: Monitoring of Anti-impotence Drugs and Their Analogues in Food Korean J. of Food Sci. Technol., 43(6), 675-682 (2011). https://doi.org/10.9721/KJFST.2011.43.6.675
  15. Sabina S, Cristiana C, Francesco B.: Detection of sibutramine administration, a gaschromatography/mass spectrometry study of the main urinary metabolites. Rapid Commun. Mass.Sp., 21, 79-88 (2007). https://doi.org/10.1002/rcm.2807
  16. So Hyun Kim, Jeongmi Lee, Taehyung Yoon, Jangduck Choi, Dongmi Choi, Deukjoon Kim and Sung Won Kwon,: Simultaneous determination of anti-diabetes/anti-obesity drugs LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS. Biomed.Chromatogr., 23, 1259-1265 (2009). https://doi.org/10.1002/bmc.1248
  17. Dwyer JT, Allison DB, Coates PM.: Dietary supplements inweight reduction. J. Am. Diet. Assoc., 105, 80-86 (2005). https://doi.org/10.1016/j.jada.2005.02.028
  18. Kwon CH, Yoon TH, Oh JH, Lee KH, Choi DM.: Elucidation and analysis of desmethylsibutramine in food. J. Food Hyg. Safety, 25, 30-35 (2010).
  19. Hae-geun Hong, Seon-jae Bang, Kwang-hee Park, In-Sook Lee, In-jung Park.: Astudy on contents of anti-impotence drug/drug-like compounds in food Korean J. Sanitation, 22(3), 89-96 (2007).
  20. Zou P, Hou P, Oh SS, Chong Ym, Bloodworth BC, Low MY, Koh HL.: Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements. J. Pharm. Biomed. Anal., 47, 279-284 (2008). https://doi.org/10.1016/j.jpba.2008.01.016
  21. KFDA: PDE-5 Inhibitors and their analogues detection survey. Korea Food & Drug Administration, Seoul, Korea, 2-4 (2006).
  22. Jin-hwan Hong.: Monitoring and elucidation of novel illegal compounds in foods Korea Food & Drug Administration, Seoul, Korea (2012).
  23. Yong-cheol Lee, Bog-soon Kim, Eun-sun Yun, Sung-dan Kim.: Monitoring of forbidden medicines as adulterants in dietary supplements marketed online by HPLC and ESI-tandom mass spectrometry J. of Food Sci. Technol., 44(2), 148-154 (2012).
  24. Yong-cheol Lee, Ju-sung Park, Sung-Dan Kim, Hye-Ran Yang, Eun-Hee Kim, Yun-Jung Yi, Sung-Ja Cho, Han-Bin Jo, Jung-Hun Kim, Young-Zoo Chae.: Simultaneous Determination of Non-steroidal Anti-inflammatory Drugs and Corticosteroids Added to Foods as Adulterants using LCESI-tandem Mass Spectrometry. J. Food Hyg. Safety, 247-251 (2013).