Toxicological Research

  • 제31권1호
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  • Pages.25-32
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  • 2015
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Ethnic Differences in the Metabolism of Toluene: Comparisons between Korean and Foreign Workers Exposed to Toluene

  • Kim, Ki-Woong (Occupational Safety and Health Research Institute, KOSHA) ;
  • Won, Young Lim (Occupational Safety and Health Research Institute, KOSHA) ;
  • Ko, Kyung Sun (Occupational Safety and Health Research Institute, KOSHA)
  • 투고 : 2015.02.24
  • 심사 : 2015.03.23
  • 발행 : 2015.03.31
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초록

The objectives of this study were to investigate the individual characteristics, lifestyle habits, exposure levels, and genetic diversity of xenobiotic-metabolizing enzymes involved in toluene metabolism in Korean and foreign workers exposed to toluene at a manufacturing plant. This study was conducted to determine the effects of culture or ethnicity on toluene metabolism. The results showed that blood and urinary toluene concentrations were dependent on the level of exposure to toluene. We analyzed the correlation between toluene metabolism and genetic diversity in glutathione S-transferase (GST) (M1), GSTT1, and cytochrome p-450 (CYP) $2E1^*5$ as well as lifestyle habits (smoking, drinking, and exercise habits). The results revealed significant correlations between toluene metabolism and GSTM1 and GSTT1 genetic diversity, as well as smoking and exercise.

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피인용 문헌

  1. Effects of Styrene-metabolizing Enzyme Polymorphisms and Lifestyle Behaviors on Blood Styrene and Urinary Metabolite Levels in Workers Chronically Exposed to Styrene vol.31, pp.4, 2015, https://doi.org/10.5487/TR.2015.31.4.355