Journal of Dairy Science and Biotechnology

  • 제33권3호
  • /
  • Pages.179-196
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  • 2015
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  • 2733-4554(pISSN)
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  • 2733-4562(eISSN)
한국낙농식품응용생물학회 (Korean Society of Dairy Science and Biotechnology)
권호 표지

유제품의 치매와 노화에 의한 인지 감소 예방 효과: 총설

Usability and Preventive Effect of Dairy- and Milk-Derived Isolates for Dementia and Age-Related Cognitive Decline: A Review

  • 천정환 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 김현숙 (한양대학교 생활과학대학 식품영양학과) ;
  • 김동현 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 김홍석 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 송광영 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 임진혁 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 최다솜 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 김영지 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 강일병 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 이수경 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 서건호 (건국대학교 수의과대학 및 KU 식품안전연구소)
  • Chon, Jung-Whan (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Kim, Hyun-Sook (Dept. of Food & Nutrition, College of Human Ecology, Hanyang University) ;
  • Kim, Dong-Hyeon (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Kim, Hong-Seok (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Song, Kwang-Young (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Yim, Jin-Hyuk (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Choi, Dasom (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Kim, Young-Ji (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Kang, Il-Byung (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Lee, Soo-Kyung (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Seo, Kun-Ho (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University)
  • 투고 : 2015.08.27
  • 심사 : 2015.09.10
  • 발행 : 2015.09.30
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초록

노인 관련 인지 감소(ARCD)와 치매는 인구 고령화로의 인구에 관한 관심의 증가이다. 최근 몇 년간 ARCD와 치매를 예방할 수 있을지 효과적인 식이에 중점을 두고 상당한 연구가 집중적으로 진행되었다. 반면에 다양한 유제품이 대사 증후군, 심혈관 건강과 같은 생리적 건강에 효과를 주는 연구가 일부 진행되었다. 따라서 향후에는 유제품이 노화 과정 중에 건강한 뇌 기능을 증진시킬 수 있는 연구가 현재 절실히 필요한 상황이다. 현재 이 총설논문에서는 대사 증후군과 포도당 조절에 유제품의 긍정적인 효과와 신경인지 건강에 영향에 대한 것도 고려되었다. 특히, 낙농 성분들, 유제품, 우유, 치즈, 요구르트, probiotics, 유청단백질, ${\alpha}$-락트알부민, 칼슘, 비타민 $B_{12}$, 생리활성 펩티드와 colostrinin(CLN) 등이 인지에 미차는 영향들에 관해서 다양한 문헌들이 수집되고 정리되었다. 또한 인지, 인지 감소, 치매, 알츠하이머 병, 대사 증후군, 당뇨인슐린 저항성, 포도당 조절 등은 인지와 건강사이에서 유제품의 역할을 집중 조사하였다. 낙농 유제품에서 발견되는 SFA와 다른 지방산도 정리되었다. 생리활성 펩티드, CLN과 proline이 풍부한 폴리펩타이드, ${\alpha}$-락트알부민, 비타민 $B_{12}$, 칼슘과 probiotic과 연관하여 뇌의 신경인지에 긍정적인 효과 등에 관해서 조사되었다. 따라서 이러한 유익한 효과를 주는 물질의 추출과 정제에 관해서도 많은 관심과 연구가 요구되어진다. 일반적으로 균형된 식사를 정기적으로 섭취할 경우, 저지방 유제품은 노화과정 중에 신경인지 건강에 유익한 효과를 가지는 것으로 밝혀지고 있다. 따라서 이러한 연구 결과를 기반으로 우유의 이용가능성을 더욱더 확대할 수 있는 관련 연구가 향후 집중적이며 지속적으로 진행되어야 할 것으로 사료된다.

Because of our aging population, there is increasing concern about the impact of dementia and age-related cognitive decline. Intense research efforts on effective dietary interventions for the prevention or amelioration of dementia and age-related cognitive decline have indicated that dairy products affect physiological health and potentially healthy brain function during aging. Milk is a rich source of proteins and peptides with nutritional and immunotropic activities. The preparation of biologically active proteins and peptides generally requires enzymatic degradation, chemical modification, or the addition of specific co-factors. Milk-derived preparations are widely available in the food industry in the form of hygiene products and infant formulas. However, milk-derived products could also be applied as preventive or therapeutic measures for a wide-range of pathological conditions not only in neonates and infants but also in adults, including the elderly. Because they have no adverse side effects, milk-derived proteins and peptides could be used as a supplementary treatment for dementia and age-related cognitive decline.

키워드

참고문헌

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