Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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Long and short range order structural analysis of In-situ formed biphasic calcium phosphates

  • Kim, Dong-Hyun (School of Materials Science and Engineering, Pusan National University) ;
  • Hwang, Kyu-Hong (School of Nano and Advanced Materials, Gyeongsang National University) ;
  • Lee, Ju Dong (Korea Institute of Industrial Technology) ;
  • Park, Hong-Chae (School of Materials Science and Engineering, Pusan National University) ;
  • Yoon, Seog-Young (School of Materials Science and Engineering, Pusan National University)
  • Received : 2015.03.04
  • Accepted : 2015.05.09
  • Published : 2015.09.30
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Abstract

Background: Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of in-situ formed BCP consisting of hydroxyapatite (HAp) and ${\beta}$-tricalcium phosphate (${\beta}$-TCP) were controlled by the degree of calcium deficiency of precursors. The long and short range order structures of biphasic mixtures was investigated using Rietveld refinement technique and high resolution Raman spectroscopy. The refined structural parameters of in-situ formed BCP confirmed that all the investigated structures have crystallized in the corresponding hexagonal (space group P63/m) and rhombohedral (space group R3c) structures. Results: The crystal phases, Ca/P molar ratio, and lattice parameters of in-situ formed BCP consisting of HAp and ${\beta}$-TCP were controlled by the degree of calcium deficiency of calcium phosphate precursors. The significant short range order structural change of BCP was determined by Raman analysis. Conclusions: The long and short range order structural changes of in-situ formed BCP might be due to the coexistence of ${\beta}$-TCP and HAp crystal phases.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

References

  1. De Groot K. Clinical applications of calcium phosphate biomaterials: a review. Ceram Int. 1993;19:363-6. https://doi.org/10.1016/0272-8842(93)90050-2
  2. Jarcho M. Biomaterial aspects of calcium phosphates. Dent Clin North Am. 1986;30:25-47.
  3. Bucholz RW, Carlton A, Holmes RE. Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthop Clin North Am. 1987;18:323-34.
  4. Hench LL, Am J. Bioceramics. Ceram Soc. 1998;81:1705-28.
  5. Klein CPAT, Driessen AA, De Groot K, van den Hooff A, Biomed J. Biodegradation behaviour of various calcium phosphate materials in bone tissue. Mater Res A. 1983;17:769-84.
  6. Dorozhkin SV, Epple M. Biological and Medical Significance of Calcium Phosphates. Angew Chem Int Ed. 2002;41:3130-46. https://doi.org/10.1002/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1
  7. Yamada S, Heyman D, Bouler JM, Daculsi G. Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/$\beta$-tricalcium phosphate ratios. Biomaterials. 1997;18:1037-41. https://doi.org/10.1016/S0142-9612(97)00036-7
  8. Bouler JM, LeGeros RZ, Daculsi G, Biomed J. Biphasic calcium phosphates: influence of three synthesis parameters on the HA/$\beta$-TCP ratio. Mater Res A. 2000;51:680-4.
  9. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop Relat Res. 1981;157:259-78.
  10. Pena J, Vallet-Regi M, Euro J. Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique. Ceram Soc. 2003;23:1687-96. https://doi.org/10.1016/S0955-2219(02)00369-2
  11. LeGeros RZ, Lin S, Rohanizadeh R, Mijares D, LeGeros JP. Biphasic calcium phosphate bioceramics: preparation, properties and applications. Mater Sci Mater Med. 2003;14:201-9. https://doi.org/10.1023/A:1022872421333
  12. Vallet-Regi M. Ceramics for medical applications. J Chem Soc Dalton Trans. 2001;97-108.
  13. Chang BS, Lee CK, Hong KS, Youn HJ, Ryu HS, Chung SS, et al. Osteoconduction at porous hydroxyapatite with various pore configurations. Biomaterials. 2000;21:1291-8. https://doi.org/10.1016/S0142-9612(00)00030-2
  14. Santos C, Martins MA, Franke RP, Almeida MM, Costa MEV. Calcium phosphate granules for use as a 5-Fluorouracil delivery system. Ceram Int. 2009;35:1587-94. https://doi.org/10.1016/j.ceramint.2008.08.015
  15. Nihouannen DL, Guehennec LL, Rouillon T, Pilet P, Bilban M, Layrolle P, et al. Micro-architecture of calcium phosphate granules and fibrin glue composites for bone tissue engineering. Biomaterials. 2006;27:2716-22. https://doi.org/10.1016/j.biomaterials.2005.11.038
  16. Kamitakahara M, Imai R, Ioku K. Preparation and evaluation of spherical Ca-deficient hydroxyapatite granules with controlled surface microstructure as drug carriers. Mater Sci Eng C. 2013;33:2446-50. https://doi.org/10.1016/j.msec.2013.01.017
  17. Kim DH, Chun HH, Lee JD, Yoon SY. Evaluation of phase transformation behavior in biphasic calcium phosphate with controlled spherical micro-granule architecture. Ceram Int. 2014;40:5145-55. https://doi.org/10.1016/j.ceramint.2013.10.064
  18. Kim DH, Park SS, Lee JD, Park HC, Yoon SY. Phase transformation behavior of spherical tricalcium phosphate micro-granules prepared by a jet wheel impact atomization and calcination process. Powder Technol. 2014;257:74-82. https://doi.org/10.1016/j.powtec.2014.02.055

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