Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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Polymeric nanocarrier systems for photodynamic therapy

  • Li, Li (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Huh, Kang Moo (Department of Polymer Science and Engineering, Chungnam National University)
  • Received : 2014.08.07
  • Accepted : 2014.10.02
  • Published : 2015.03.31
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Abstract

Photodynamic therapy (PDT) is an emerging treatment modality that involves the combined action of photosensitizers (PSs) and light for treatment of solid tumor and other diseases. Although this therapeutic method has been considered as an alternative to classical cancer treatments, clinical PDT requires further advances in selectivity and therapeutic efficacy to overcome numerous shortages related to conventional PDT. In this regard, great efforts have been devoted to the development of polymeric nanocarrier-encapsulated PSs for targeted PDT, aiming at improvement of water solubility and tumor-specificity of hydrophobic PSs. Here, we discuss the general concepts and considerations of polymeric nanocarriers for efficient delivery of PSs. In recent, the amphiphilic PS-polymer conjugate-based self-quenchable nanoparticles and PS-polymer-conjugate/quencher nanocomplexes have emerged as an attractive delivery platform for efficient and reliable PDT. They can incorporate and deliver the PS in a photodynamically inactive state but demonstrate cytotoxic effects by tumor environment-sensitive activation mechanisms, so that the photodynamic cancer treatment can achieve maximum target specificity. Here, we report the recent achievements on the development of activatable PS formulations based on PS-polymer conjugates.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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