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The Korean Association of Immunobiologists (대한면역학회)
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Expression of the ATP-gated $P2X_7$ Receptor on M Cells and Its Modulating Role in the Mucosal Immune Environment

  • Kim, Sae-Hae (Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University) ;
  • Lee, Ha-Yan (Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University) ;
  • Jang, Yong-Suk (Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University)
  • Received : 2014.12.07
  • Accepted : 2015.02.05
  • Published : 2015.02.28
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Abstract

Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by microbe-derived molecules such as ATP and short-chain fatty acids. In this study, we undertook to characterize the expression of the ATP-gated $P2X_7$ receptor ($P2X_7R$) on M cells and its role in gastrointestinal mucosal immune regulation because it was poorly characterized in Peyer's patches, although purinergic signaling via $P2X_7R$ and luminal ATP have been considered to play an important role in the gastrointestinal tract. Here, we present the first report on the expression of $P2X_7R$ on M cells and characterize the role of $P2X_7R$ in immune enhancement by ATP or LL-37.

Keywords

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