IMMUNE NETWORK

  • 제15권1호
  • /
  • Pages.37-43
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  • 2015
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Lactoferrin Combined with Retinoic Acid Stimulates B1 Cells to Express IgA Isotype and Gut-homing Molecules

  • Kang, Seong-Ho (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University) ;
  • Jin, Bo-Ra (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University) ;
  • Kim, Hyeon-Jin (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University) ;
  • Seo, Goo-Young (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University) ;
  • Jang, Young-Saeng (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University) ;
  • Kim, Sun-Jin (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University) ;
  • An, Sun-Jin (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University) ;
  • Park, Seok-Rae (Department of Microbiology, College of Medicine, Konyang University) ;
  • Kim, Woan-Sub (Department of Animal Life and Environmental Science, College of Agriculture and Life Science, Hankyong National University) ;
  • Kim, Pyeung-Hyeun (Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University)
  • 투고 : 2014.11.22
  • 심사 : 2015.01.26
  • 발행 : 2015.02.28
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초록

It is well established that TGF-${\beta}1$ and retinoic acid (RA) cause IgA isotype switching in mice. We recently found that lactoferrin (LF) also has an activity of IgA isotype switching in spleen B cells. The present study explored the effect of LF on the Ig production by mouse peritoneal B cells. LF, like TGF-${\beta}1$, substantially increased IgA production in peritoneal B1 cells but little in peritoneal B2 cells. In contrast, LF increased IgG2b production in peritoneal B2 cells much more strongly than in peritoneal B1 cells. LF in combination with RA further enhanced the IgA production and, interestingly, this enhancement was restricted to IgA isotype and B1 cells. Similarly, the combination of the two molecules also led to expression of gut homing molecules ${\alpha}4{\beta}7$ and CCR9 on peritoneal B1 cells, but not on peritoneal B2 cells. Thus, these results indicate that LF and RA can contribute to gut IgA response through stimulating IgA isotype switching and expression of gut-homing molecules in peritoneal B1 cells.

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참고문헌

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  3. Antibacterial and immunomodulatory activities of bovine lactoferrin against Escherichia coli O157:H7 infections in cattle vol.31, pp.3, 2018, https://doi.org/10.1007/s10534-018-0082-x
  4. Retinoic Acid, Leaky Gut, and Autoimmune Diseases vol.10, pp.8, 2015, https://doi.org/10.3390/nu10081016
  5. Specialized immune responses in the peritoneal cavity and omentum vol.109, pp.4, 2015, https://doi.org/10.1002/jlb.5mir0720-271rr