Journal of Korean Neurosurgical Society

  • 제57권2호
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  • Pages.73-76
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  • 2015
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Effects of Tumor Necrosis Factor Alpha Blocker Adalimumab in Experimental Spinal Cord Injury

  • Borcek, Alp Ozgun (Department of Neurosurgery, Gazi University Faculty of Medicine) ;
  • Civi, Soner (Department of Neurosurgery, Medicana Private Hospital) ;
  • Ocal, Ozgur (Department of Neurosurgery, Gazi University Faculty of Medicine) ;
  • Gulbahar, Ozlem (Department of Biochemistry, Gazi University Faculty of Medicine)
  • 투고 : 2014.03.10
  • 심사 : 2014.08.24
  • 발행 : 2015.02.28
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초록

Objective : Tumor necrosis factor alpha (TNF-${\alpha}$) have proven effects in pathogenesis of neuroinflammation after spinal cord injury (SCI). Current study is designed to evaluate the effects of an anti-TNF-${\alpha}$ agent, adalimumab, on spinal cord clip compression injury in rats. Methods : Thirty two male adult Wistar rats were divided into four groups (sham, trauma, infliximab, and adalimumab groups) and SCI was introduced using an aneurysm clip. Animals in treatment groups received 5 mg/kg subcutaneous adalimumab and infliximab right after the trauma. Malondialdehyde (MDA) levels were studied in traumatized spinal cord tissues 72 hours after the injury as a marker of lipid peroxidation. Results : Animals that received anti-TNF-${\alpha}$ agents are found to have significantly decreased MDA levels. MDA levels were significantly different between the trauma and infliximab groups (p<0.01) and trauma and adalimumab groups (p=0.022). There was no significant difference in neurological evaluation of the rats using Tarlov scale. Conclusion : These results suggest that, like infliximab, adalimumab has favorable effects on lipid peroxidation induced by spinal cord trauma in rats.

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피인용 문헌

  1. Current Agents and Related Therapeutic Targets for Inflammation After Acute Traumatic Spinal Cord Injury vol.132, pp.None, 2019, https://doi.org/10.1016/j.wneu.2019.08.108
  2. Novel inhibitors of Rho-kinase mediated neuroinflammatory pathways and their potential application in recovery of injured spinal cord vol.38, pp.16, 2020, https://doi.org/10.1080/07391102.2019.1686066