Horticultural Science & Technology (원예과학기술지)

Korean Society of Horticultural Science (한국원예학회)
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Biosafety and Toxicological Evaluation of Tissue-Cultured Echinacea purpurea Adventitious Roots

  • Murthy, Hosakatte Niranjana (Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University) ;
  • Park, So-Young (Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University) ;
  • Lee, Eun Jeong (Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University) ;
  • Paek, Kee Yoeup (Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University)
  • Received : 2014.06.08
  • Accepted : 2014.09.17
  • Published : 2015.02.28
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Abstract

Echinacea purpurea (L.) Moench (purple cone flower) is an important medicinal plant; it can enhance immunity, relieve pain, and reduce inflammation, and also has hormonal, antiviral, and antioxidant effects. Adventitious root biomass of Echinacea purpurea was produced in commercial-scale bioreactors for use as a dietary supplement in the food industry and in traditional medicine. Biosafety and toxicological evaluations of tissue-cultured Echinacea purpurea adventitious roots (TCEPARs) were performed. Reverse mutation and chromosomal aberration tests showed no significant mutagenicity. Furthermore, repeated four-week oral dose tests performed in Sprague-Dawley rats did not show any notable changes in the general behavior of the rats, in the gross appearance of their internal organs, or in their mortality rate. There were no differences between the control group and the treatment group in parameters such as absolute body weight, hematology, blood chemistry, and absolute and relative organ weights. These findings indicate that TCEPARs are safe and nontoxic when consumed at an average dietary level and can be used as raw material for traditional medicine and the food industry.

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References

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