Biomolecules & Therapeutics

  • 제23권2호
  • /
  • Pages.134-140
  • /
  • 2015
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  • 1976-9148(pISSN)
  • /
  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells

  • Kim, Kui-Jin (Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland) ;
  • Lee, Jihye (Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland) ;
  • Park, Yeonhwa (Department of Food Science, University of Massachusetts) ;
  • Lee, Seong-Ho (Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland)
  • 투고 : 2014.09.29
  • 심사 : 2014.12.11
  • 발행 : 2015.03.01
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초록

Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to the ATF/CREB family of transcription factors and is associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which t10, c12-CLA stimulates ATF3 expression and apoptosis in human colorectal cancer cells. t10, c12-CLA increased an apoptosis in human colorectal cancer cells in dose dependent manner. t10, c12-CLA induced ATF3 mRNA and luciferase activity of ATF3 promoter in a dose-dependent manner. The responsible region for ATF3 transcriptional activation by t10, c12-CLA is located between -147 and -1850 of ATF3 promoter. mRNA stability of ATF3 was not affected by t10, c12-CLA treatment. t10, c12-CLA increases $GSK3{\beta}$ expression and suppresses IGF-1-stimulated phosphorylation of Akt. The knockdown of ATF3 suppressed expression of $GSK3{\beta}$ and NAG-1 and PARP cleavage. The results suggest that t10, c12-CLA induces apoptosis through ATF3-mediated pathway in human colorectal cancer cells.

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참고문헌

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