한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제32권1호
  • /
  • Pages.62-68
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  • 2015
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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말의 제엽염 진단을 위한 특이적 생물지표

A Specific Biomarker for The Diagnosis of Equine Laminitis

  • Lee, Seungwoo (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Seung Heon (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Myung-Chul (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Yong-Baek (College of Veterinary Medicine, Seoul National University) ;
  • Ryu, Doug-Young (College of Veterinary Medicine, Seoul National University)
  • 심사 : 2014.01.25
  • 발행 : 2015.02.28
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초록

There is no reliable indicator available for the diagnosis of horse laminitis, although the disease is common and costly. This study was performed to develop a specific diagnostic biomarker for laminitis. We have identified 33 differentially expressed proteins in plasma of a horse suffering laminitis that is experimentally induced by an overdose of oligofructose, in comparison with normal horse plasma. Among the proteins, myosin-9 mRNA was found in RNA sequencing analysis to be expressed specifically in laminitis tissues compared to other horse tissues. It is thus suggested that expression of plasma myosin-9 may be used for the diagnosis of equine laminitis.

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참고문헌

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