Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Immunomodulatory Effects of Zingiber officinale in Cyclophosphamide-induced Immunosuppress Mice

Cyclophosphamide로 유발된 면역억제 마우스에서 생강의 면역 억제 효과

  • Koo, Sung-Wook (College of Veterinary Medicine, Kyungpook National University) ;
  • Lim, Mee-Kyung (School of Healthcare and Biotechnology, Kyungwoon University) ;
  • Lee, Keun-Woo (College of Veterinary Medicine, Kyungpook National University)
  • 구성욱 (경북대학교 수의과대학) ;
  • 임미경 (경운대학교 보건바이오학과) ;
  • 이근우 (경북대학교 수의과대학)
  • Accepted : 2014.12.08
  • Published : 2015.02.28
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Abstract

The object of this study was to find out the immunomodulatory effects of Ginger Aqueous extracts, as compared with that of ${\beta}$-glucan well-known an immune modulator, on the cyclophosphamide (CPA) induced immunosuppress mice. To induce immunosuppress, 150 and 110 mg/kg of CPA were dissolved in saline and injected intraperitoneally at 3 or 1 day before start of test article administration, respectively. ${\beta}$-glucan or gingers (125, 250, 500 mg/kg) were dosed, 4 times at 12-hr intervals starting 24hrs after last CPA-treatment. Distilled water was used as a vehicle and each groups were used 10 mice. As results of twice intraperitoneal CPA treatment, decreases in the body weight and gain, weight of thymus, spleen. However these CPA-induced immunosuppress changes were inhibited by treatment of three different dosages of ginger or ${\beta}$-glucan as compared with CPA control. Similar favorable inhibitory activities on weight and histopathological change of spleen and thymus induced CPA treatment were detected between ${\beta}$-glucan and ginger 250 mg/kg treated groups.

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References

  1. 박광원, 이아름, 이인영, 김미경, 백인기. $\beta$-Glucan 제제들 이 산란계의 생산성, 혈액 성상과 소장내 미생물 균총 및 면역 체계에 미치는 영향. 한국가금학회지 2008; 35: 183-190.
  2. 손종연. 향신료 메탄올 추출물의 항산화 및 항균효과. 한국식품영양과학회지 2010; 39: 648-654.
  3. 이재곤, 장희진, 곽재진, 이동욱. 추출방법에 따른 생강의 휘발성 성분조성 비교. 한국식품영양학회지.2000; 13: 66-70.
  4. Aeschbach R, Loliger J, Scott BC, Murcia A, Butler J, Halliwell B, Aruoma OI. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol 1994; 32: 31-36. https://doi.org/10.1016/0278-6915(84)90033-4
  5. Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger Extract Consumption Reduces Plasma Cholesterol, Inhibits LDL Oxidation and Attenuates Development of Atherosclerosis in Atherosclerotic, Apolipoprotein E-Deficient Mice. J Nutr 2000; 130: 1124-1131. https://doi.org/10.1093/jn/130.5.1124
  6. Hong JH, Ryu KW, Ryu BH, Yoon SH, Kim JS. The inhibitory effects of Soarngudamikgitang on the side effects of cyclophosphamide. Korean J Onent Int Med 2002; 23: 123-132.
  7. Kulicke WM, Lettau AI, Thielking H. Correlation between immunological activity, molar mass, and molecular structure of different (1$\rightarrow$3)-$\beta$-D-glucans. Carbohydr Res 1997; 297: 135-143. https://doi.org/10.1016/S0008-6215(96)00273-X
  8. Miyauchi A, Hiramine C, Tananka S, Hojo K. Differential effects of a single dose of cyclophosphamide on T cell subsets of the thymus and spleen in mice : Flow ctyofluorometry analysis. Tohoku J Exp Med 1990; 162: 147-167. https://doi.org/10.1620/tjem.162.147
  9. Park HR, Jo SK, Jung UH, Kim DH, Yee ST. Immunomodulatory Effect of a New Herbal Preparation (HemoHIM) in Cyclophosphamide-treated Mice. J Food Sci Nutr 2006; 11: 54-60. https://doi.org/10.3746/jfn.2006.11.1.054
  10. Pyo MY, Hyun SM, Yang KS. Effects of Phellinus linteus extracts on the humoral immune response in normal and cyclophosphamide-treated mice. Biomol Ther 2001; 9: 194-200.
  11. Sekiwa Y, Kubota K, Kobayashi A. Isolation of Novel Glucosides Related to Gingerdiol from Ginger and Their Antioxidative Activities. J Agric Food Chem 2000; 48: 373-377. https://doi.org/10.1021/jf990674x
  12. Son CG, Han SH, Cho JH, Shin JW, Cho CH, Lee YW, Cho CK. Induction of hemopoiesis by saenghyuldan, a mixture of ginseng radix, paeoniae radix alba, and hominis placenta extracts. Acta Pharmacol Sin 2003; 24: 120-126.