Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Predictive Role of Neutrophil Gelatinase-Associated Lipocalin in Early Diagnosis of Platin-Induced Renal Injury

  • Seker, Mehmet Metin (Medical Oncology Department, Faculty of Medicine, Cumhuriyet University) ;
  • Deveci, Koksal (Biochemistry Department, Faculty of Medicine, Cumhuriyet University) ;
  • Seker, Ayse (Public Health Directorate) ;
  • Sancakdar, Enver (Biochemistry Department, Faculty of Medicine, Cumhuriyet University) ;
  • Yilmaz, Ali (Internal Medicine Department, Faculty of Medicine, Cumhuriyet University) ;
  • Turesin, A. Kerim (Internal Medicine Department, Faculty of Medicine, Cumhuriyet University) ;
  • Kacan, Turgut (Medical Oncology Department, Faculty of Medicine, Cumhuriyet University) ;
  • Babacan, Nalan A. (Medical Oncology Department, Faculty of Medicine, Cumhuriyet University)
  • Published : 2015.02.25
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Abstract

Background: Acute kidney injury is an important issue in chemotherapy receiving patients an neutrophil gelatinase-associated lipocalin has been proposed as a novel marker. We here aimed to assess the role of urinary levels for assessment after platin exposure. Materials and Methods: Patients who had treated with cisplatin or carboplatin or oxaliplatin containg regimens were included in this study. Baseline and postchemotherapy serum urea, creatinine, urine neutrophil gelatinase-associated lipocalin and urine creatinine levels were determined. To avoid the effects of hydration during chemotherapy infusion the urinary neutrophil gelatinase-associated lipocalin/urine creatinine ratio was used to determine acute kidney injury. Results: Of a total of 42 patients receiving platin compounds,14 (33.3%) received cisplatin containing regimens, 14 (33.3%) received carboplatin and 14 (33.3%) oxaliplatin. The median age was 60 (37-76) years. Nineteen of the patients (45.2%) had lung cancer, 12 (28.6%) colorectal cancer and 11 (26.2%) others. The median pre and post chemotherapy urine neutrophil gelatinase-associated lipocalin/urine creatinin ratio was 15.6 ng/mg and 35.8 ng/mg (p=0.041) in the cisplatin group, 32.5 ng/mg and 86.3 ng/mg (p=0.004) in the carboplatin group and 40.9 ng/mg and 62.3 ng/mg (p=0.243) in the oxaliplatin group. Conclusions: Nephrotoxicity is a serious side effect of chemotherapeutic agentslike cisplatin and carbopaltin, but only to a lower extent oxaliplatin. All platin compounds must be used carefully and urine neutrophil gelatinase-associated lipocalin measurement seems to be promising in detecting acute kidney injury earlier than with creatinine.

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References

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