Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Genome Wide Association Studies Using Multiple-lactation Breeding Value in Holsteins

  • Cho, Kwang-Hyun (National Institute of Animal Science, RDA) ;
  • Oh, Jae-Don (Animal Genomics and Breeding Center, Hankyong National University) ;
  • Kim, Hee-Bal (Department of Agricultural Biotechnology, Seoul National University) ;
  • Park, Kyung-Do (Animal Genomics and Breeding Center, Hankyong National University) ;
  • Lee, Joon-Ho (Animal Genomics and Breeding Center, Hankyong National University)
  • Received : 2014.05.09
  • Accepted : 2014.10.20
  • Published : 2015.03.01
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Abstract

A genome wide association study was conducted using estimated breeding value (EBV) for milk production traits from 1st to 4th lactation. Significant single nucleotide polymorphism (SNP) markers were selected for each trait and the differences were compared by lactation. DNA samples were taken from 456 animals with EBV which are Holstein proven bulls whose semen is being sold or the daughters of old proven bulls whose semen is no longer being sold in Korea. High density genome wide SNP genotype was investigated and the significance of markers associated with traits was tested using the breeding value estimated by a multiple lactation model as a dependent variant. As the result of significance comparisons by lactations, several differences were found between the first lactation and subsequent lactations (from second to 4th lactation). A similar trend was noted in mean deviation and correlation of the estimated effects by lactation. Since there was a difference in the genes associated with EBV for each trait between first and subsequent lactations, a multi-lactation model in which lactation is considered as a different trait is genetically useful. Also, significant markers in all lactations and common markers for different traits were detected, which can be used as markers for quantitative trait loci exploration and marker assisted selection in milk production traits.

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References

  1. Browning, S. R. and B. L. Browning. 2007. Rapid and accurate haplotype phasing and missing-data inference for wholegenome association studies by use of localized haplotype clustering. Am. J. Hum. Genet. 81:1084-1097. https://doi.org/10.1086/521987
  2. Guo, J., H. Jorjani, and O. Carlborg. 2012. A genome-wide association study using international breeding-evaluation data identifies major loci affecting production traits and stature in the Brown Swiss cattle breed. BMC Genetics 13:82.
  3. Hayes, B. J., J. Pryce, A. J. Chamberlain, P. J. Bowman, and M. E. Goddard. 2010. Genetic architecture of complex traits and accuracy of genomic prediction: Coat colour, milk-fat percentage, and type in holstein cattle as contrasting model traits. PloS Genet. 6(9):e1001139. https://doi.org/10.1371/journal.pgen.1001139
  4. Jamrozik, J., L. R. Schaeffer, Z. Liu, and G. Jansen. 1997. Multiple trait random regression test day model for production traits. Interbull Bulletin 16:43-47
  5. Jiang, L., J. Liu, D. Sun, P. Ma, X. Ding, Y. Yu, and Q. Zhang. 2010. Genome wide association studies for milk production traits in Chinese Holstein population. PLoS ONE 5(10):e13661. https://doi.org/10.1371/journal.pone.0013661
  6. Liu, Z. and J. C. M. Dekkers. 1998. Least squares interval mapping of quantitative trait loci under the infinitesimal genetic model in outbred populations. Genetics 148:495-505.
  7. Liu, Z., F. Reinhardt, and R. Reents. 2002. Genetics correlation estimates of a multiple lactation multiple country model for milk production traits based on performance records. Interbull Bulletin 29:12-17.
  8. Mai, M. D., G. Sahana, F. B. Christiansen, and B. Guldbrandtsen. 2010. A genome-wide association study for milk production traits in Danish Jersey cattle using a 50K single nucleotide polymorphism chip. J. Anim. Sci. 88:3522-3528 https://doi.org/10.2527/jas.2009-2713
  9. Meredith, B. K., F. J. Kearney, E. K. Finlay, D. G. Bradley, A. G. Fahey, D. P. Berry, and D. J. Lynn. 2012. Genome-wide associations for milk production and somatic cell score in Holstein-Friesian cattle in Ireland. BMC Genetics 13:21.
  10. Minozzi1, G., E. L. Nicolazzi1, A. Stella, B. Biffani, R. Negrini, B. Lazzari, P. Ajmone-Marsan, and J. L. Williams. 2013. Genome wide analysis of fertility and production traits in Italian Holstein cattle. PLoS ONE 8(11):e80219. https://doi.org/10.1371/journal.pone.0080219
  11. Pryce, J. E., S. Bolormaa, A. J. Chamberlain, P. J. Bowman, K. Savin, M. E. Goddard, and B. J. Hayes. 2010. A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypes. J. Dairy Sci. 93:3331-3345. https://doi.org/10.3168/jds.2009-2893